Prevention of oxalate urolithiasis by some compounds.
Prevention of oxalate urolithiasis by some compounds.
复制标题
通过某些化合物预防草酸盐尿石症。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
Lewis Ld
中科院分区：
文献类型：
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作者：
Chow Fh;Hamar Dw;Boulay Jp;Lewis Ld
：雄性Wistar大鼠饲喂基础饲料、Purina Laboratory Chow和草酸钙生产饲料（CPD）。CPD是含有3%乙醇酸的基础饮食。将丙酮酸钠、DL-丙氨酸、α-酮基谷氨酸、焦磷酸硫胺素和L-谷氨酸加入CPD中，以确定其预防结石形成的有效性。通过将甲基乙二醛添加到饮用水中来确定其有效性。喂食CPD 4周的大鼠在输尿管、膀胱、肾小管和/或肾盂和乳头中出现结石。喂食丙氨酸和/或丙酮酸盐组的大鼠在其肾小管或输尿管中没有结石;此外，这些大鼠的肾盂和膀胱中沉积物的发生率和量显著降低。喂食α-酮基谷氨酸、焦磷酸硫胺素、L-谷氨酸和甲基乙二醛的组中的大鼠比单独喂食CPD的组中的大鼠发生了同等或更严重的草酸盐尿石症。本研究的结果显示，适当水平的丙酮酸或丙氨酸可能有助于防止草酸盐尿石形成。
: Male Wistar rats were fed a basal diet, Purina Laboratory Chow, and an oxalate calculi-producing diet (CPD). The CPD was the basal diet containing 3 per cent glycolic acid. Sodium pyruvate, DL-alanine, alpha-keto glutaric acid, thiamine pyrophosphate, and L-glutamic acid were added to the CPD to determine their effectiveness in preventing calculi formation. The effectiveness of methyl glyoxal was determined by adding it to the drinking water. Rats fed CPD for 4 weeks developed calculi in the ureters, bladder, renal tubules, and/or renal pelvis and papilla. Rats in groups fed alanine and/or pyruvate had no calculi in their renal tubules or ureters; additionally, these rats had a significant reduction in incidence and amount of deposits in the renal pelvis and bladder. Rats in groups fed alpha-keto glutaric acid, thiamine pyrophosphate, L-glutamic acid, and methyl glyoxal developed equally or more severe oxalate urolithiasis than those on CPD alone. Results of this study show that either pyruvate or alanine at appropriate levels may be beneficial in preventing oxalate urolith formation.