Acetylcholine receptor: complex of homologous subunits.
Acetylcholine receptor: complex of homologous subunits.
复制标题
乙酰胆碱受体：同源亚基的复合体。
作者：
M. Raftery;M. Hunkapiller;C. Strader;L. Hood
来自加利福尼亚电鳐的乙酰胆碱受体由五个亚基组成；其中两个是相同的，另外三个在结构上与它们相关。四种多肽的微序列分析表明其亚基之间的氨基酸同源性。对膜结合受体和triton溶解受体进行进一步的序列分析，得到4个亚基（40000:50000:60000:65000道尔顿）的化学计量为2:1:1:1，表明该蛋白是一个分子量为255000道尔顿的五聚体复合物。系谱分析表明，从一个共同的祖先基因的分化发生在受体进化的早期。这种共同的祖先认为，这四个亚基中的每一个都在受体的生理活动中发挥着功能作用。
The acetylcholine receptor from the electric ray Torpedo californica is composed of five subunits; two are identical and the other three are structurally related to them. Microsequence analysis of the four polypeptides demonstrates amino acid homology among the subunits. Further sequence analysis of both membrane-bound and Triton-solubilized, chromatographically purified receptor gave the stoichiometry of the four subunits (40,000:50,000:60,000:65,000 daltons) as 2:1:1:1, indicating that this protein is a pentameric complex with a molecular weight of 255,000 daltons. Genealogical analysis suggests that divergence from a common ancestral gene occurred early in the evolution of the receptor. This shared ancestry argues that each of the four subunits plays a functional role in the receptor's physiological action.