Fabrication and characterization of forcespun polycaprolactone microfiber scaffolds
Fabrication and characterization of forcespun polycaprolactone microfiber scaffolds
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DOI：
10.1088/2053-1591/abcac1
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发表时间：
2020-12-01
影响因子：
2.3
通讯作者：
Rangari, Vijaya K.
中科院分区：
文献类型：
--
作者：
Kodali, Deepa;Syed, Farooq;Rangari, Vijaya K.
采用强压技术制备亚微米级聚己内酯(PCL)纤维。与使用静电力的静电纺丝方法不同，强制纺丝方法使用离心力来产生纤维。PCL已被广泛用作细胞再生的支架、组织工程的基质和药物输送系统。本研究的目的是对力纺纤维毡进行定性分析，研究喷丝板转速对纤维形态、热性能和力学性能的影响。用扫描电子显微镜、差示扫描量热仪、拉伸试验和动态力学分析对抽提纤维进行了表征。结果表明，转速越高，纤维越均匀，珠粒数越少。纤维的结晶度随转速的增加而降低。强力纺纤维的杨氏模数在3.5~6兆帕范围内。储能模数和损耗模数随纤维直径的增大而减小。与短距离收集的纤维相比，距离喷丝板较远收集的纤维具有最佳的力学性能。这项研究将有助于提取具有均匀几何形状和较低珠子的纤维，以实现所需的纳米纤维药物释放性能。
Forcespinning technique was used to fabricate sub-micron size polycaprolactone (PCL) fibers. Forcespinning method uses centrifugal forces for the generation of fibers unlike the electrospinning method which uses electrostatic force. PCL has been extensively used as scaffolds for cell regeneration, substrates for tissue engineering and in drug delivery systems. The aim of this study is to qualitatively analyze the force spun fiber mats and investigate the effect of the spinneret rotational speed on the fiber morphology, thermal and mechanical properties. The extracted fibers were characterized by scanning electron microscopy differential scanning calorimetry, tensile testing and dynamic mechanical analysis. The results showed that higher rotational speeds produced uniform fibers with less number of beads. The crystallinity of the fibers decreased with increase in rotational speeds. The Young's modulus of the forcespun fibers was found to be in the range of 3.5 to 6 MPa. Storage and loss moduli decreased with the increase in the fiber diameter. The fibers collected at farther distance from spinneret exhibited optimal mechanical properties compared to the fibers collected at shorter distances. This study will aid in extracting fibers with uniform geometries and lower beads to achieve the desired nanofiber drug release properties.