The Analysis of Illicit Methaqualone Containing Preparations by Gas Chromatography–Mass Spectrometry for Forensic Purposes
The Analysis of Illicit Methaqualone Containing Preparations by Gas Chromatography–Mass Spectrometry for Forensic Purposes
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DOI：
10.1111/j.1556-4029.2006.00053.x
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发表时间：
2006-03
影响因子：
1.6
通讯作者：
A. Grove;E. Rohwer;J. Laurens;B. Vorster
中科院分区：
文献类型：
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作者：
A. Grove;E. Rohwer;J. Laurens;B. Vorster
摘要：建立了一种气相色谱-质谱联用法定量分析非法制剂中甲喹酮的方法。该方法的变异系数低于5%。分析了四批缉获的片剂，其中两对具有相似印记。结果发现，所有4批片剂的平均MTQ浓度存在显著差异（p=0.01），因此无法得出结论，仅根据MTQ浓度，具有相似标志的批次来自相同的生产商或生产批次。相反，可以说，在这种情况下，这四批来自不同的秘密制药厂或不同的制造批次。
ABSTRACT: A validated gas chromatographic–mass spectrometric method for quantitative analysis of methaqualone (MTQ) in illicit preparations is reported. The method proved to have a coefficient of variation of below 5%. Four batches of seized tablets, two pairs with similar imprints, were analyzed. It was found that the average MTQ concentration in all four batches of tablets differed significantly (p=0.01) rendering it impossible to conclude that, on the basis of MTQ concentration alone, the batches with a similar logo originated from the same manufacturer or manufacturing batch. Conversely, it can be said that in this case, the four batches originated from either different clandestine laboratories or manufacturing batches.