Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy
Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy
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DOI：
10.1007/s10143-005-0398-1
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发表时间：
2005-08
影响因子：
2.8
通讯作者：
F. Yamasaki;J. Takaba;M. Ohtaki;N. Abe;Y. Kajiwara;T. Saito;H. Yoshioka;S. Hama;T. Akimitsu;K. Sugiyama;K. Arita;K. Kurisu
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文献类型：
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作者：
F. Yamasaki;J. Takaba;M. Ohtaki;N. Abe;Y. Kajiwara;T. Saito;H. Yoshioka;S. Hama;T. Akimitsu;K. Sugiyama;K. Arita;K. Kurisu
乳酸和脂类的信号在单体素质子磁共振光谱（1HMRS）中部分重叠，有时使它们在临床环境中难以区分。我们在这项研究中的目的是通过改变回声时间（TE）来识别乳酸和脂质。我们期望乳酸和脂质的准确检测在脑肿瘤的诊断中具有较高的诊断价值。根据我们的方案，我们从1999年8月至2004年2月期间的213例患者中获得了有意义的hmrs谱，其中包括163例脑肿瘤患者。hmrs的TE为144 ms， TE为30 ms，必要时TE为288 ms。213例患者中，47例患者乳酸水平为“阴性”，131例患者为“阳性”，35例患者为“强阳性”。脂质水平为“阴性”90例，“阳性”56例，“强阳性”67例。根据WHO分级和乳酸和脂质水平的logistic判别分析，WHO分级2级和3级之间乳酸和脂质水平显著（P=0.0239），分级3级和4级之间显著（P=0.0347）。对于WHO 2级和3级（P=0.0073）以及3级和4级（P=0.0048）之间的区别，脂质是一个更重要的因素。利用我们的方法改变TE，可以准确有效地检测大脑中的乳酸和脂质。我们发现乳酸和脂质表达与神经上皮肿瘤的WHO分级有显著的相关性。
The signals of lactate and lipids partially overlap in single-voxel proton MR spectroscopy (1HMRS), sometimes making them difficult to differentiate in clinical settings. Our aim in this study was to identify lactate and lipids by varying the echo time (TE). We expect that the accurate detection of lactate and lipids will have high diagnostic value in the diagnosis of brain tumors. Following our protocol, we obtained meaningful1HMRS spectra from 213 patients, including 163 patients with brain tumors, between August 1999 and February 2004.1HMRS was performed with a TE of 144 ms followed by a TE of 30 ms and/or a TE of 288 ms, if necessary. For the 213 patients, lactate level was “negative” in 47 patients, “positive” in 131 patients, and “strongly positive” in 35 patients. The lipid level was “negative” in 90 patients, “positive” in 56 patients, and “strongly positive” in 67 patients. Based on logistic discriminant analyses of neuro-epithelial tumor WHO grade and lactate and lipid levels, lactate and lipid levels were significant between WHO grades 2 and 3 (P=0.0239) and between grades 3 and 4 (P=0.0347). Lipids are a more significant factor for the discrimination between WHO grades 2 and 3 (P=0.0073) and between grades 3 and 4 (P=0.0048). With our method of varying the TE, it is possible accurately and efficiently to detect lactate and lipids in the brain. We found a significant correlation between lactate and lipid expression and WHO grade of neuro-epithelial tumors.