LASER DOPPLER MEASUREMENT OF GINGIVAL BLOOD-FLOW IN DOGS WITH INCREASING AND DECREASING INFLAMMATION
LASER DOPPLER MEASUREMENT OF GINGIVAL BLOOD-FLOW IN DOGS WITH INCREASING AND DECREASING INFLAMMATION
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DOI：
10.1016/0003-9969(87)90063-x
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发表时间：
1987-01-01
影响因子：
3
通讯作者：
OBERG, PA
中科院分区：
文献类型：
--
作者：
BAAB, DA;OBERG, PA
血管形态和血管化的显着变化与狗牙龈炎的早期临床症状有关。有相互矛盾的证据表明发炎牙龈的血流量增加和减少。通过一种新的非侵入性技术——激光多普勒流量计（LDF），对狗治疗和未治疗牙龈炎的血流速率进行了比较。 LDF 通过背向散射光测量牙龈边缘 1 mm3 的血流量。四只患有全身性轻度牙龈炎的成年杂种狗被喂食会引起牙菌斑的饮食。左边的牙齿在零周和第四周时进行了刮牙和抛光，并在七周的实验期间每周刷牙六次；右边的牙齿没有得到治疗。测试牙齿是上犬齿到第四前磨牙，以及下第二前磨牙到第一磨牙。在这些牙齿的面部方面，在第零周、第一周、第四周和第七周评估了菌斑指数 (P1I)、牙龈指数 (GI) 和龈沟液 (GCF)。在第一周、第四周和第七周时用 LDF 测量牙龈边缘的血流量。在每次后续检查时，使用丙烯酸器具将光纤探头重新定位在同一位置。在条件二元 Logistic 回归模型中，P1I、GI 和 GCF 与治疗显着相关 (p < 0.01)，但 LDF 血流量则不然 (p = 0.01)。未治疗侧的血流量随着时间的推移略有增加，但随着治疗侧炎症的消退，血流量没有显着减少。因此，牙龈炎症的微血管变化可能不会很快逆转（如果有的话）。
Dramatic changes in vessel morphology and vascularization are associated with early clinical signs of gingivitis in the dog; there is conflicting evidence of both increased and decreased blood flow in the inflamed gingiva. The blood-flow rates were compared in treated and untreated gingivitis in dogs by a new, non-invasive technique, the laser Doppler flow meter (LDF). The LDF measures blood flow in 1 mm3 of the gingival margin by back-scattered light. Four adult mongrel dogs with generalized mild gingivitis were fed a dental-plaque-inducing diet. Teeth on the left were scaled and polished at zero and four weeks and brushed six times a week during the seven-week experimental period; teeth on the right were left untreated. Test teeth were the upper canines through to the fourth premolars, and lower second premolars through to the first molars. On the facial aspect of these teeth, plaque index (P1I), gingival index (GI), and gingival crevicular fluid (GCF) were assessed at weeks zero, one, four and seven. Blood flow at the gingival margin was measured with LDF at weeks one, four and seven. Acrylic appliances were used to reposition the fibre-optic probe in the same place at each follow-up examination. In a conditional binary logistic regression model, P1I, GI and GCF were significantly related to treatment (p < 0.01), but LDF blood flow was not (p = 0.01). Blood flow increased slightly with time on the untreated side, but there was no significant decrease in blood flow with the resolution of inflammation on the treated side. Thus microvascular changes in gingival inflammation may not quickly, if ever, be reversed.