Different inhibitory synaptic input patterns in excitatory and inhibitory layer 4 neurons of ferret visual cortex.
Different inhibitory synaptic input patterns in excitatory and inhibitory layer 4 neurons of ferret visual cortex.
复制标题
雪貂视觉皮层兴奋性和抑制性第 4 层神经元的不同抑制性突触输入模式。
DOI：
10.1093/cercor/13.4.350
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kao,JosephP-Y
中科院分区：
文献类型：
--
作者：
Roerig,Birgit;Chen,Bingzhong;Kao,JosephP-Y
The synaptic mechanisms underlying the generation of orientation and direction selectivity in layer 4 of the primary visual cortex are still largely unclear. Previousin vivowork has shown that intra-cortical inhibition plays a major role in generating the properties of orientation and direction selectivity. Excitatory and inhibitory cortical neurons differ in their receptive field properties: excitatory neurons tend to be orientation- and direction-selective, inhibitory neurons tend to be orientation-, but not direction-selective. Here we have compared the relationship between direction preference maps recordedin vivoand synaptic input maps recordedin vitrofrom excitatory and inhibitory stellate cells in layer 4 of ferret visual cortex. Our goal was to test whether the differences in direction tuning between these cell populations might result from different inhibitory connectivity patterns. We found that excitatory neurons, which are direction tunedin vivo, receive ∼50% of their inhibitory inputs from cortical regions of opposite direction preference whereas inhibitory cells, which are not or poorly direction tuned, receive only very few inputs from regions of opposite direction preference. This confirms that inhibitory connections arising in cortical regions of opposite direction preference may be required to create or strengthen direction tuning in their target neurons. Thus, differences in intracortical inhibitory circuit patterns may underlie the differences in receptive field properties observed between excitatory and inhibitory neuronsin vivo.
