Ultrasound triggered release of cisplatin from liposomes in murine tumors
Ultrasound triggered release of cisplatin from liposomes in murine tumors
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DOI：
10.1016/j.jconrel.2009.03.007
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发表时间：
2009-07-01
影响因子：
10.8
通讯作者：
Barenholz, Yechezkel
中科院分区：
文献类型：
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作者：
Schroeder, Avi;Honen, Reuma;Barenholz, Yechezkel
低频超声（LFUS）在体外触发药物从纳米空间稳定脂质体（nSSL）释放的能力，而不影响药物的化学完整性或生物学效力，以前已经被证明。在此，研究了LFUS（a）触发顺铂从nSSL中释放和（B）通过局部释放药物影响治疗功效的能力。为此，将nSSL负载的体内抗癌化疗剂顺铂腹膜内（i.p.）在其腹膜腔中携带发育良好的J6456鼠淋巴瘤肿瘤的小鼠。然后，将LFUS外部应用于腹壁120秒，并量化药物释放。在暴露于LFUS的肿瘤中，近70%的脂质体顺铂被释放，相比之下，
The ability of low frequency ultrasound (LFUS) to trigger the release of drugs from nano sterically stabilized liposomes (nSSL) in vitro, without affecting the drugs' chemical integrity or biological potency, has been previously shown. Herein, the ability of LFUS to (a) trigger the release of cisplatin from nSSL in and (b) affect the therapeutic efficacy by locally releasing the drug, was studied. For this, nSSL loaded vivo, with the anti-cancer chemotherapeutic agent cisplatin were injected intraperitoneally (i.p.) to mice bearing well-developed J6456 murine lymphoma tumors in their peritoneal cavity. Then, LFUS was applied externally to the abdominal wall for 120 s, and drug release was quantified. Nearly 70% of the liposomal cisplatin was released in tumors exposed to LFUS, compared to