The effect of nisoldipine on whole blood platelet aggregation in patients with Raynaud's phenomenon.
The effect of nisoldipine on whole blood platelet aggregation in patients with Raynaud's phenomenon.
复制标题
尼索地平对雷诺现象患者全血血小板聚集的影响。
DOI：
10.1111/j.1365-2125.1988.tb05262.x
复制
发表时间：
1988
影响因子：
3.4
通讯作者：
DG Waller
中科院分区：
文献类型：
--
作者：
JL Francis;O. Roath;VF Challenor;DG Waller
1. Whole blood platelet aggregation was measured by electrical impedance in 28 controls and 28 patients with primary Raynaud's phenomenon. 2. The patients were entered into a double-blind, placebo-controlled cross-over trial of the calcium antagonist nisoldipine, in which they received, in random order, three, 4 week treatments with placebo and nisoldipine (5 and 10 mg day-1). 3. Platelet aggregation responses to two concentrations (5.0 and 0.5 micrograms ml-1) of collagen were determined before treatment and at the end of each treatment phase. 4. There were no differences in aggregation response to either collagen concentration between controls and patients with primary Raynaud's phenomenon, or between placebo and active treatment phases. 5. These data do not support the suggestion that nisoldipine has a significant anti-platelet effect.
