Functionalized Gold Nanoparticles and Their Biomedical Applications.
Functionalized Gold Nanoparticles and Their Biomedical Applications.
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DOI：
10.3390/nano1010031
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发表时间：
2011-06-14
期刊：
影响因子：
--
通讯作者：
Singh SR
中科院分区：
文献类型：
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作者：
Tiwari PM;Vig K;Dennis VA;Singh SR
金属纳米颗粒由于其小的尺寸体积比和广泛的热稳定性而被广泛地用于各种生物医学应用中。金纳米粒子（GNP）由于其易于合成和功能化、毒性小和易于检测而成为一个明显的选择。本文综述了GNP功能化的各种方法及其在生物医学研究中的应用。功能化促进了这些纳米颗粒向各种细胞类型的靶向递送、生物成像、基因递送、药物递送和其他治疗和诊断应用。本文综述了金纳米粒子功能化的最新进展及其在医学和生物学领域的潜在应用。
Metal nanoparticles are being extensively used in various biomedical applications due to their small size to volume ratio and extensive thermal stability. Gold nanoparticles (GNPs) are an obvious choice due to their amenability of synthesis and functionalization, less toxicity and ease of detection. The present review focuses on various methods of functionalization of GNPs and their applications in biomedical research. Functionalization facilitates targeted delivery of these nanoparticles to various cell types, bioimaging, gene delivery, drug delivery and other therapeutic and diagnostic applications. This review is an amalgamation of recent advances in the field of functionalization of gold nanoparticles and their potential applications in the field of medicine and biology.