Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival.
Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival.
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DOI：
10.1016/j.biopha.2018.11.031
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
Yi-qi Yang;Jian Liang;Xiao-dong Han;R. Tian;Xusheng Liu;W. Mao;Hong-tao Xu;Bo Liu;Peng Xu-P
中科院分区：
文献类型：
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作者：
Yi-qi Yang;Jian Liang;Xiao-dong Han;R. Tian;Xusheng Liu;W. Mao;Hong-tao Xu;Bo Liu;Peng Xu-P
雷公藤内酯（tritriolide, T11）是从中药雷公藤中提取的天然二萜二氧化物。F(雷公藤)从结构的角度来看，t11与雷公藤甲素（T9）非常相似，雷公藤甲素是近几十年来系统研究的雷公藤甲素中最有效的化合物之一。然而，由于其在植物器官中的丰度较低，t11的基本功能和药用特性尚未得到很好的研究。本研究旨在探讨t11对嘌呤霉素氨基核苷（PAN）诱导的小鼠足细胞凋亡的保护作用及其机制。结果表明，高剂量下，att11对足细胞无明显毒性，对PAN诱导的足细胞损伤有明显的保护作用。进一步研究表明，att11可能通过抑制PAN诱导足细胞的凋亡，恢复足细胞的存活来发挥其保护作用。
Triptriolide (T11) is a natural diterpene diepoxide that derived from Chinese traditional herb medicine (TCHM)Tripterygium wilfordiiHook.F (TWHF). From a structural point of view,T11is very similar to triptolide (T9), one of the most effectively compounds in TWHF that have already been systematically investigated in the past decades. However, the basic functions and medicinal properties ofT11have not yet been well investigated mainly due to its low abundance in its plant organ. The present study aimed to investigate the protective effects ofT11on puromycin aminonucleoside (PAN) induced apoptotic mouse podocytes and the underlying mechanism. The results showed thatT11had no significant toxicity in podocytes in high dosage, and showed prominent protective effects on PAN induced podocytes injury. Further studies indicated thatT11might exert its protective effects by inhibiting of apoptosis and restoring of survival in PAN induced podocytes.