The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study.
The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study.
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吸烟者和非吸烟者的假关节（手术骨不连）发生率：一项比较研究。
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发表时间：
1986
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通讯作者：
Richardson Hd
中科院分区：
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作者：
Brown Cw;Orme Tj;Richardson Hd
摘要为了研究吸烟与假关节（手术性骨不连）发生率的关系，随机选择了50例吸烟患者和50例非吸烟患者，这些患者在1977年和1978年期间接受了双节段椎板切除融合术。大多数参与者都遭受了与工作有关的伤害，而其他人的背部功能障碍没有共同的病因。大多数患者来自美国东南部。年龄范围为23岁至62岁，吸烟者的平均年龄为42.4岁，不吸烟者的平均年龄为42.7岁。男女代表人数相等，少数民族代表人数按其在人口中的总百分比计算。手术后1 - 2年的检查显示，40%（20）的吸烟者形成了假关节，而在不吸烟者中，这一比例为8%（4）。这一发现似乎与年龄、性别或种族无关，具有统计学显著性（卡方= 14.035，P = .001）。据推测，吸烟者手术不愈合的发生率较高可能与血气水平有关。不吸烟者没有表现出明显的不足，而吸烟者显示平均PO 2水平为78.5%（正常= 95-97），平均O2饱和度水平为92.9%（正常= 95或以上）。最后，本研究亦提出进一步研究的建议。
Abstract To investigate the relationship of smoking with the rate of pseudarthrosis (surgical nonunion), 50 patients, who were smokers, and 50 patients, who were not, and who had had a two-level laminectomy and fusion during 1977 and 1978 were randomly selected for this study. Most of those participating had sustained job-related injuries whereas the others had no common etiology for their back dysfunction. Most of the patients were from the southeastern United States. Ages ranged from 23 to 62 years, with a mean age of 42.4 years for smokers and 42.7 years for nonsmokers. There was an equal representation of males and females, with minorities represented according to their general percentage in the population. Examination 1 to 2 years after surgery revealed that 40% (20) of the smokers had developed a pseudarthrosis, whereas among nonsmokers, the rate was 8% (4). This finding appears to be independent of age, sex, or race and was statistically significant (chi 2 = 14.035, P = .001). It was hypothesized that the higher incidence of surgical nonunion among smokers may be related to blood gas levels. Nonsmokers showed no significant deficiencies, whereas smokers showed a mean PO2 level of 78.5% (normal = 95-97) and a mean O2 saturation level of 92.9% (normal = 95 or above). Implications and suggestions for further research are also discussed.