Causes and mechanisms of nondipping hypertension
Causes and mechanisms of nondipping hypertension
复制标题
DOI：
10.1080/10641960802251974
复制
发表时间：
2008-01-01
影响因子：
12.3
通讯作者：
Covic, Adrian
中科院分区：
文献类型：
--
作者：
Kanbay, Mehmet;Turgut, Faruk;Covic, Adrian
越来越多的证据表明，不用勺子的人比用勺子的人心血管结果更差。动态血压监测缺乏夜间血压下降(非降压)也被证明与靶器官损害和心血管预后恶化的关系比降压型高血压患者更密切。非浸泡与心血管疾病之间潜在的潜在致病机制尚不完全清楚。夜间血压下降可能有多种潜在的病理生理机制。外在和内在因素，包括神经激素调节异常，缺乏体力活动，营养因素，如膳食钠摄入量增加，以及吸烟，都与迟钝的血压昼夜节律有关。某些疾病，如糖尿病和慢性肾脏疾病，也会影响昼夜血压节律。目前，非浸泡的临床重要性已为人所熟知；然而，某些疾病状态与非浸泡之间的关系尚未完全解释。这篇论文将试图阐明非浸泡的潜在基础以及与各种疾病状态的具体联系。
Growing evidence indicates that nondippers have worsened cardiovascular outcomes than dippers. Ambulatory blood pressure monitoring with a lack of nocturnal BP fall (nondipping) have also been shown to be more closely associated with target organ damage and worsened cardiovascular outcome than in patients with essential hypertension with dipping pattern. The underlying pathogenetic mechanisms potentially linking nondipping with cardiovascular disease are not fully understood. There are multiple possible underlying pathophysiologic mechanisms in the impaired BP decline during the night. Extrinsic and intrinsic factors including abnormal neurohormonal regulation, lack of physical activity, nutritional factors such as increased dietary sodium intake, and smoking of tobacco have been implicated for blunted circadian rhythm of BP. Certain diseases such as diabetes and chronic renal diseases also affect the circadian BP rhythm. Currently, the clinical importance of nondipping is known well; however, the relationship between certain disease states and nondipping has not been fully explained yet. This paper will attempt to address to clarify the underlying basis for nondipping and the specific associations with various disease states.