Residual antimicrobial activity after canal irrigation with chlorhexidine
Residual antimicrobial activity after canal irrigation with chlorhexidine
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DOI：
10.1016/s0099-2399(97)80052-0
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发表时间：
1997-04-01
影响因子：
4.2
通讯作者：
Janer, LR
中科院分区：
文献类型：
--
作者：
White, RR;Hays, GL;Janer, LR
我们以前报道过2.0%洗必泰根管冲洗液的体外抗菌活性与5.25%次氯酸钠相当。本研究的目的是确定洗必泰冲洗液是否能在离体器械根管内注入实质性的抗菌活性。器械固定后，用无菌水填充根管，并在处理后6、12、24、48和72 h用纸尖吸收根管液样品，通过将纸尖置于接种有变形链球菌的琼脂平板表面并测量抑菌圈来测定纸尖的抗菌活性，抗菌活性存在于所有2.0%洗必泰治疗的牙齿在整个72小时的测试期间，并在大多数牙齿，在相对较低的浓度，6至24小时后冲洗0.12%洗必泰。这些结果表明，洗必泰灌输实质性的抗菌活性时，用作根管冲洗。
We previously reported that the in vitro antimicrobial activity of a 2.0% chlorhexidine endodontic irrigant was equivalent to that of 5.25% sodium hypochlorite. The purpose of this study was to determine if chlorhexidine irrigants could instill substantive antimicrobial activity in instrumented root canals in vitro, Human teeth were instrumented using 2.0% or 0.12% chlorhexidine as irrigants. After instrumentation, the root canals were filled with sterile water, and samples of the root canal fluid were absorbed with paper points at 6, 12, 24, 48, and 72 h after treatment, The paper points were assayed for antimicrobial activity by placing them on agar plate surfaces inoculated with Streptococcus mutans and measuring zones of inhibition, Antimicrobial activity was present in all 2.0% chlorhexidine-treated teeth throughout the 72-h testing period and in most teeth, in relatively lower concentrations, for 6 to 24 h after irrigation with 0.12% chlorhexidine. These results indicate that chlorhexidine instills substantive antimicrobial activity when used as an endodontic irrigant.