Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-Blocker Therapy in Chronic Obstructive Pulmonary Disease.
Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-Blocker Therapy in Chronic Obstructive Pulmonary Disease.
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计算机断层扫描的心脏形态测量和慢性阻塞性肺疾病β-受体阻滞剂治疗减轻病情加重。
DOI：
10.1164/rccm.201702-0399le
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发表时间：
2017
影响因子：
24.7
通讯作者：
Washko,G
中科院分区：
文献类型：
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作者：
Bhatt,SuryaP;Vegas-Sánchez-Ferrero,Gonzalo;Rahaghi,FarbodN;MacLean,ErickS;Gonzalez-Serrano,German;Come,CarolynE;Kinney,GregoryL;Hokanson,JohnE;Budoff,MatthewJ;Cuttica,MichaelJ;Wells,JMichael;Estépar,RaúlSanJosé;Washko,G
方法我们纳入了来自多中心 COPDGene 队列的 3,436 名患有中度至重度 COPD 的参与者（详细信息先前发布；ClinicalTrials.gov NCT00608764）(4)。在入组时记录药物数据，并且我们每 3 至 6 个月前瞻性地联系参与者以确定恶化频率 (2)。如前所述，使用基于心脏结构非仿射变形的统计模型来进行心脏分割以及心室体积和球形度的测量，以模拟解剖变异性，通过手动初始化进行分割，然后对模型进行自动迭代变形以适合心脏表面 (3)。左心室和右心室体积是根据心外膜表面拟合估计的，包括心室壁和心室体积。 LV 和 RV 球形度定义为与空腔体积相同的球体表面积除以空腔实际表面积的比率 (3)。我们还使用标准 DICOM 软件（OsiriX DICOM Viewer，版本 4.0；Bernex，瑞士）测量了主肺动脉 (PA) 分叉处的直径与同一水平升主动脉直径的比率 (5)。
MethodsWe included 3,436 participants with moderate to severe COPD from the multicenter COPDGene cohort (details published previously; ClinicalTrials. gov NCT00608764)(4). Medication data were recorded at enrollment, and we contacted participants prospectively every 3 to 6 months to ascertain exacerbation frequency (2). As previously described, cardiac segmentation and measurement of ventricular volume and sphericity were performed using a statistical model based on nonaffine deformations of cardiac structure to model anatomic variability, with segmentation performed by manual initialization followed by automated, iterative deformation of the model to fit the surface of the heart (3). LV and RV volume were estimated on the basis of the epicardial surface fit and included both the wall and chamber volume. LV and RV sphericity were defined by the ratio of surface area of a sphere the same volume as the cavity divided by the actual surface area of the cavity (3). We also measured the ratio of the diameter of the main pulmonary artery (PA) at the level of its bifurcation to the diameter of the ascending aorta at the same level, using standard DICOM software (OsiriX DICOM Viewer, version 4.0; Bernex, Switzerland)(5).