THIGMOTAXIS AS AN INDEX OF ANXIETY IN MICE - INFLUENCE OF DOPAMINERGIC TRANSMISSIONS
THIGMOTAXIS AS AN INDEX OF ANXIETY IN MICE - INFLUENCE OF DOPAMINERGIC TRANSMISSIONS
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DOI：
10.1016/0166-4328(94)90008-6
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发表时间：
1994-03-31
影响因子：
2.7
通讯作者：
COSTENTIN, J
中科院分区：
文献类型：
--
作者：
SIMON, P;DUPUIS, R;COSTENTIN, J
当小鼠被引入一个开放区域时，它们倾向于主要探索该开放区域的外围区域。这种保持靠近岩壁的倾向，被称为靠近性，在探索的最初几分钟内逐渐减弱。我们考虑了在这段时间内的趋动性程度作为小鼠焦虑的一个指标。这一假设已被几种参考抗焦虑药物（右安非他明、戊四唑、育亨宾、咪唑嗪）证实，这些药物增加了抗焦虑性；抗焦虑药物（丁螺环酮，苯巴比妥）也能减少焦虑。在该试验中，选择性或非选择性间接多巴胺激动剂GBR 12783、右安非他明和可卡因均可诱导thmomotaxis增加。最后，D1和D2多巴胺受体的同时参与已经证明了与多巴胺能传递增加相关的焦虑样效应。
When mice are introduced into an open-field, they are inclined to explore mainly the peripheral zone of this open-field. This tendency to remain close the walls, called thigmotaxis, decreases gradually during the first minutes of exploration. We have considered the degree of thigmotaxis during this period of decrease as an index of anxiety in mice. This hypothesis has been validated with several reference anxiogenic drugs (dexamphetamine, pentylenetetrazole, yohimbine, idazoxan) which increased thigmotaxis; and with anxiolytic drugs (buspirone, phenobarbital), which reduced it. On this test the selective or non-selective indirect dopamine agonists GBR 12783, dexamphetamine and cocaine induced an increase of thigmotaxis. Finally, the simultaneous involvement of D1 and D2 dopamine receptors has been evidenced in the anxiogenic-like effect associated with an increase of dopaminergic transmissions.