A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape
A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape
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DOI：
10.1038/hdy.2008.79
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发表时间：
2008-12-01
期刊：
影响因子：
3.8
通讯作者：
Cheverud, J. M.
中科院分区：
文献类型：
--
作者：
Leamy, L. J.;Klingenberg, C. P.;Cheverud, J. M.
基因组印迹是指依赖于亲本来源的单等位基因表达模式，即一个位点上的两个等位基因中的一个表达而另一个沉默。虽然已知小鼠中的一些基因是印迹的，但印迹的真正范围及其对广泛形态特征的遗传结构的影响大多是未知的。因此，我们在来自LG/J（大）和SM/J（小）自交系杂交的F(3)大群体小鼠中寻找显示下颌骨大小和形状性状印迹效应的数量性状位点（QTL）。我们共发现51个影响下颌骨大小和形状的QTL，其中6个在相互杂合子之间表现出差异，这是印迹效应的通常特征。然而，我们的分析表明，这些QTL中只有一个（影响下颌骨大小）表现出与真正的印迹效应一致的模式，而其他五个的互杂合子差异都是由于母体遗传效应。我们得出的结论是，基因组印记对这些特定的形态特征的影响可以忽略不计，并且母体遗传效应可能解释了许多先前报道的明显基因组印记的实例。遗传（2008）101,518-526；doi: 10.1038 / hdy.2008.79;2008年8月6日在网上发表
Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F(3) population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting. Heredity (2008) 101, 518-526; doi: 10.1038/hdy.2008.79;published online 6 August 2008