Plasma insulinlike growth factor I and binding-protein 3 and risk of myocardial infarction in women: A prospective study
Plasma insulinlike growth factor I and binding-protein 3 and risk of myocardial infarction in women: A prospective study
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DOI：
10.1373/clinchem.2008.105825
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发表时间：
2008-10-01
影响因子：
9.3
通讯作者：
Hankinson, Susan E.
中科院分区：
文献类型：
--
作者：
Page, John H.;Ma, Jing;Hankinson, Susan E.
背景：这项研究的目的是前瞻性地评估胰岛素样生长因子1(IGF1)和胰岛素样生长因子结合蛋白3(IGFBP3)浓度与女性继发性心肌梗死(MI)之间的关系。方法：我们使用病例对照抽样从已经被选入未来护士健康研究队列的女性中选择研究参与者。1989-1990年间采集了32826名妇女的血样。在从样本采集到1998年6月的随访期间，245名妇女被诊断为心肌梗塞(致命性和非致命性)。根据年龄、吸烟状况以及采血时的月份和禁食状况，这些病例与对照组的比例为1：2。应用条件Logistic回归分析调整潜在混杂因素(绝经状态、父母MI病史、绝经后激素使用、糖尿病、高血压、高胆固醇血症、阿司匹林使用、饮酒、体重指数和体力活动)。结果：多因素调整分析未显示IGF1或IGFBP3浓度或其摩尔比与MI风险之间存在统计学意义的线性关系。IGF1四分位数最高的女性与IGF1四分位数最低的女性相比，MI的多变量调整率为1.46(95%可信区间0.79，2.72；趋势P=0.46)。IGFBP3和IGFI：IGFBP3摩尔/L比值的对应比率(95%CI)分别为1.24(0.71，2.17)和1.29(0.70，2.37)。结论：在绝经后妇女中未发现IGF1或IGFBP3与MI之间存在单调关系。未来的研究有必要评估包括年轻女性在内的其他人口群体中的这些关系。(C)2008年美国临床化学协会。
BACKGROUND: The aim of this study was to prospectively evaluate relationships between plasma concentrations of insulinlike growth factor 1 (IGF 1) and insulinlike growth factor binding protein 3 (IGFBP3) and subsequent myocardial infarction (MI) in women.METHODS: We used case-control sampling to select study participants from women who had already been selected for inclusion in the prospective Nurses' Health Study cohort. Blood samples were collected from 32 826 women in 1989-1990. During the follow-up period from sample collection through June 1998, MI (fatal and nonfatal) was diagnosed in 245 women. Cases were matched to controls 1:2 by age, cigarette-smoking status, and month and fasting status at the time of blood collection. Conditional logistic regression was used to adjust for potential confounders (menopausal status, parental history of MI, postmenopausal hormone use, diabetes mellitus, hypertension, hypercholesterolemia, aspirin use, alcohol use, body mass index, and physical activity).RESULTS: Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of MI. Women in the highest IGF1 quartile had a multivariable-adjusted rate ratio of 1.46 (95% CI 0.79, 2.72; P for trend = 0.46) for MI, compared with those in the lowest. The corresponding rate ratios (95% CI) for IGFBP3 and the IGF I:IGFBP3 mol/L ratio were 1.24 (0.71, 2.17) and 1.29 (0.70, 2.37), respectively.CONCLUSIONS: We did not observe a monotonic relationship between IGF1 or IGFBP3 and MI among predominantly postmenopausal women. Future studies are warranted to evaluate these relationships in other demographic groups including younger women. (c) 2008 American Association for Clinical Chemistry.