Signal quality of simultaneously recorded invasive and non-invasive EEG
Signal quality of simultaneously recorded invasive and non-invasive EEG
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DOI：
10.1016/j.neuroimage.2009.02.028
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发表时间：
2009-07-01
期刊：
影响因子：
5.7
通讯作者：
Schulze-Bonhage, Andreas
中科院分区：
文献类型：
--
作者：
Ball, Tonio;Kern, Markus;Schulze-Bonhage, Andreas
来自人脑的有创和无创脑电记录在神经科学研究中发挥着越来越重要的作用，是医学脑机接口的候选模式。人们通常认为，有创脑电记录中不存在影响非侵入性脑电的主要伪影，如眨眼和眼球运动引起的伪影。然而，就伪影污染而言，缺乏对同时记录的有创和非有创脑电信号质量的定量研究。在这里，我们比较了非侵入性和侵袭性脑电中与眨眼相关的伪影，使用一种适合于检测微小伪影污染的方法，同时从前额叶和运动皮质区域记录了眨眼相关伪影。正如预期的那样，我们发现眨眼在前额叶和运动皮质区域上方的非侵入性脑电中都会导致明显的伪影。出乎意料的是，在侵入性记录中也发现了显著的眨眼相关伪影，特别是在前额叶区域。计算伪影幅度与脑活动幅度的比值，发现有创脑电信号质量是同时获得的非有创脑电信号质量的20~100倍以上。因此，虽然我们的发现表明，有创记录中确实存在眼部伪影，但它们也突显了与非有创脑电数据相比，有创记录的信号质量要好得多。我们的发现表明，在ECoG研究的实验设计中，尤其是在分析额前区的事件相关电位时，眨眼应该被考虑在内。此外，我们的结果鼓励应用减少眼部伪影的技术来进一步优化侵入性脑电的信号质量。(C)2009 Elsevier Inc.保留所有权利。
Both invasive and non-invasive electroencephalographic (EEG) recordings from the human brain have an increasingly important role in neuroscience research and are candidate modalities for medical brain-machine interfacing. It is often assumed that the major artifacts that compromise non-invasive EEG, such as caused by blinks and eye movement, are absent in invasive EEG recordings. Quantitative investigations on the signal quality of simultaneously recorded invasive and non-invasive EEG in terms of artifact contamination are, however, lacking. Here we compared blink related artifacts in non-invasive and invasive EEG, simultaneously recorded from prefrontal and motor cortical regions using an approach suitable for detection of small artifact contamination. As expected, we find blinks to cause pronounced artifacts in non-invasive EEG both above prefrontal and motor cortical regions. Unexpectedly, significant blink related artifacts were also found in the invasive recordings, in particular in the prefrontal region. Computing a ratio of artifact amplitude to the amplitude of ongoing brain activity, we find that the signal quality of invasive EEG is 20 to above 100 times better than that of simultaneously obtained non-invasive EEG. Thus, while our findings indicate that ocular artifacts do exist in invasive recordings, they also highlight the much better signal quality of invasive compared to non-invasive EEG data. Our findings suggest that blinks should be taken into account in the experimental design of ECoG Studies, particularly when event related potentials in fronto-anterior brain regions are analyzed. Moreover, our results encourage the application of techniques for reducing ocular artifacts to further optimize the signal quality of invasive EEG. (C) 2009 Elsevier Inc. All rights reserved.