Thymic epithelial cell development and its dysfunction in human diseases.
Thymic epithelial cell development and its dysfunction in human diseases.
复制标题
胸腺上皮细胞发育及其在人类疾病中的功能障碍
DOI：
10.1155/2014/206929
复制
发表时间：
2014
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Sun L;Li H;Luo H;Zhao Y
胸腺上皮细胞（TEC）是胸腺T细胞发育微环境的重要组成部分。TEC由皮质和髓质TEC组成，来源于共同的双能祖细胞，并经历由多水平信号控制的逐步发育，以在功能上成熟，以支持胸腺细胞发育。肿瘤坏死因子受体（TNFR）家族成员包括NFκB受体激活剂（RANK）、CD 40和光敏素β受体（LTβR），它们共同调控胸腺髓质微环境和自身耐受的建立。此外，成纤维细胞生长因子（FGF）、Wnt和Notch信号对于功能性胸腺微环境的建立是必不可少的。转录因子Foxn1和自身免疫调节因子（Aire）是TEC发育、分化和自身耐受的强大调节剂。胸腺微环境的功能障碍，包括TEC和胸腺细胞发育的缺陷，会导致生理性疾病，如肿瘤、感染性疾病和自身免疫性疾病。本文就TEC的发生、分子信号通路以及胸腺功能障碍与人类疾病的关系作一综述。
Thymic epithelial cells (TECs) are the key components in thymic microenvironment for T cells development. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor and undergo a stepwise development controlled by multiple levels of signals to be functionally mature for supporting thymocyte development. Tumor necrosis factor receptor (TNFR) family members including the receptor activator for NFκB (RANK), CD40, and lymphotoxin β receptor (LTβR) cooperatively control the thymic medullary microenvironment and self-tolerance establishment. In addition, fibroblast growth factors (FGFs), Wnt, and Notch signals are essential for establishment of functional thymic microenvironment. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful modulators of TEC development, differentiation, and self-tolerance. Dysfunction in thymic microenvironment including defects of TEC and thymocyte development would cause physiological disorders such as tumor, infectious diseases, and autoimmune diseases. In the present review, we will summarize our current understanding on TEC development and the underlying molecular signals pathways and the involvement of thymus dysfunction in human diseases.
登录
查看更多内容
影响因子：
20.3
作者：
Berent-Maoz, Beata;Montecino-Rodriguez, Encarnacion;Dorshkind, Kenneth
通讯作者：
Dorshkind, Kenneth
影响因子：
64.5
作者：
Calderon, Lesly;Boehm, Thomas
通讯作者：
Boehm, Thomas
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D
影响因子：
56.9
作者：
Akiyama, T;Maeda, S;Inoue, J
通讯作者：
Inoue, J
DOI：
10.1073/pnas.93.12.5742
发表时间：
1996-06-11
影响因子：
11.1
作者：
Blackburn, CC;Augustine, CL;Morahan, G
通讯作者：
Morahan, G