Responses of insulin to oral glucose and fructose loads in marginally copper-deficient rats fed starch or fructose
Responses of insulin to oral glucose and fructose loads in marginally copper-deficient rats fed starch or fructose
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DOI：
10.1016/s0899-9007(96)91730-x
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发表时间：
1996-07-01
期刊：
影响因子：
4.4
通讯作者：
Lure, MD
中科院分区：
文献类型：
--
作者：
Fields, M;Lewis, CG;Lure, MD
这项研究的目的是评估单独或与边际铜缺乏合并饮食果糖对断奶雄性大鼠暴露于各自的饮食仅2wk的影响。这种对铜摄入量不足的短期暴露可防止因饮食铜缺乏暴露时间增加而导致的渐进性发病。给断奶雄性大鼠饲喂低铜(0.6mgCug/g)和适铜(6.0mgCug/g)含62%果糖或62%淀粉的饲料2wk。在隔夜禁食后进行口服葡萄糖或果糖耐量试验。与饲喂淀粉的大鼠相比，口服果糖的大鼠在空腹和负荷后30min时，口服葡萄糖或果糖均可提高胰岛素水平。尽管血浆胰岛素水平很高，但血糖并没有降低。边缘铜缺乏对血浆胰岛素和血糖均无影响。数据表明，果糖是导致葡萄糖代谢不良变化的唯一因素，两周的果糖摄入量就足以产生这些变化。
The purpose of this study was to assess the effects of dietary fructose either alone or in combination with marginal copper deficiency in weanling male rats exposed to their respective diets for only 2 wk. This short duration of exposure to inadequate copper intake prevents progressive morbidity brought about by increasing periods of exposure to dietary copper deprivation. Weanling male rats were fed a copper-deficient (0.6 mu g Cu/g) or a copper-adequate (6.0 mu g Cu/g) diet containing 62% fructose or 62% starch for 2 wk. Either an oral glucose or an oral fructose tolerance test was conducted after an overnight fast. Insulin levels were elevated by either oral glucose or oral fructose at fasting and at 30 min postload in rats fed fructose compared with those fed starch. Despite high levels of plasma, insulin blood glucose was not reduced. Marginal copper deficiency had no effect on either plasma insulin or blood glucose. Data identify fructose as the sole agent responsible for inducing adverse changes in glucose metabolism Two weeks of fructose consumption was sufficient to produce these changes.