A DROSOPHILA SEMINAL FLUID PROTEIN, ACP26AA, STIMULATES EGG-LAYING IN FEMALES FOR 1 DAY AFTER MATING
A DROSOPHILA SEMINAL FLUID PROTEIN, ACP26AA, STIMULATES EGG-LAYING IN FEMALES FOR 1 DAY AFTER MATING
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DOI：
10.1073/pnas.92.22.10114
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发表时间：
1995-10-24
影响因子：
11.1
通讯作者：
WOLFNER, MF
中科院分区：
文献类型：
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作者：
HERNDON, LA;WOLFNER, MF
交配触发了雌性果蝇的行为和生理变化，包括产卵量的增加。来自男性附腺的精液分子负责最初的行为变化，但这些变化的持续需要储存精子。利用遗传分析，我们已经确定了一个精液蛋白，是负责一个最初的产卵海拔。这种分子，Acp26Aa，具有激素原的结构特征，并含有一个氨基酸类似的区域，以产卵激素的Aaplasia。Acp26Aa在交配过程中转移到雌性体内，并在那里进行加工。在这里，我们报告的突变体，包括空，在Acp26Aa的生成和分析。雌性与缺乏Acp26Aa的雄性Plies交配，比正常雄性的配偶产的蛋少。这种效应仅在交配后的第一天明显。无效突变对雄性或交配的雌性没有其他可检测的生理或行为影响。
Mating triggers behavioral and physiological changes in the Drosophila melanogaster female, including an elevation of egg laying. Seminal fluid molecules from the male accessory gland are responsible for initial behavioral changes, but persistence of these changes requires stored sperm. Using genetic analysis, we have identified a seminal fluid protein that is responsible for an initial elevation of egg laying. This molecule, Acp26Aa, has structural features of a prohormone and contains a region with amino acid similarity to the egg-laying hormone of Aplysia. Acp26Aa is transferred to the female during mating, where it undergoes processing. Here we report the generation and analysis of mutants, including a null, in Acp26Aa. Females mated to male Plies that lack Acp26Aa lay fewer eggs than do mates of normal males. This effect is apparent only on the first day after mating. The null mutation has no other detectable physiological or behavioral effects on the male or the mated female.