Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.
Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.
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DOI：
10.1016/j.psyneuen.2017.02.012
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发表时间：
2017-05
影响因子：
3.7
通讯作者：
Payne JL
中科院分区：
文献类型：
--
作者：
Osborne LM;Gispen F;Sanyal A;Yenokyan G;Meilman S;Payne JL
目前关于孕酮及其代谢物在围产期情绪和焦虑障碍中的作用的证据不一。我们对60例先前诊断为情绪障碍的孕妇进行了孕中期和孕晚期（T2和T3）孕酮（PROG）和异孕酮（ALLO）水平的ELISA检测和产后抑郁（PPD）的临床访谈（DSM-IV标准）检测。方法采用多元回归和logistic回归，采用一般线性混合效应模型。我们发现，调整后，每增加ng/mL的T2 ALLO导致发生PPD的风险降低63% （95% CI 13%至84%，p = 0.022）。我们的研究结果扩展了之前将ALLO与妊娠期抑郁联系起来的工作，并表明妊娠ALLO与PPD之间的关系值得在更大的样本中进一步探索。
Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p = 0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.