Cytochromes P450 for Terpene Functionalisation and Metabolic Engineering
Cytochromes P450 for Terpene Functionalisation and Metabolic Engineering
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DOI：
10.1007/10_2014_301
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Hamberger, Bjorn
中科院分区：
文献类型：
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作者：
Pateraki, Irini;Heskes, Allison Maree;Hamberger, Bjorn
植物已经进化出产生一系列惊人的专门代谢物的能力。萜类化合物是此类化合物中最古老且最多样化的一类，并引起了工业和制药应用的兴趣。开发其生产的生物技术替代品是深入研究的焦点。光合系统为自养代谢工程提供了新策略。本综述重点关注参与核心萜分子功能化的细胞色素 P450，重点介绍了该领域的最新方法，并展望了有可能塑造萜类生物工程未来的最新发现。
Plants have evolved the capacity to produce a striking array of specialised metabolites. Terpenoids are the oldest and most diverse class of such compounds and have attracted interest for industrial and pharmaceutical applications. The development of biotechnological alternatives for their production is the focus of intense research. Photosynthetic systems provide new strategies for autotrophic metabolic engineering. Focusing on cytochromes P450, involved in the functionalisation of the core terpene molecules, this review highlights the latest approaches in this field and looks towards recent discoveries that have the potential to shape the future of terpenoid bioengineering.