The Effects of Chronic Periodontitis and Rheumatoid Arthritis on Serum and Gingival Crevicular Fluid Total Antioxidant/Oxidant Status and Oxidative Stress Index
The Effects of Chronic Periodontitis and Rheumatoid Arthritis on Serum and Gingival Crevicular Fluid Total Antioxidant/Oxidant Status and Oxidative Stress Index
复制标题
DOI：
10.1902/jop.2011.110420
复制
发表时间：
2012-06-01
影响因子：
4.3
通讯作者：
Erel, Ozcan
中科院分区：
文献类型：
--
作者：
Esen, Cagri;Alkan, Banu Arzu;Erel, Ozcan
背景：慢性牙周炎(CP)和类风湿关节炎(RA)似乎有许多共同的病理特征。氧代谢在CP和RA的发病机制中起重要作用。方法：将80例慢性炎症性疾病患者分为RA-CP组、RA组、CP组、CP组和C组，每组20例。结果：RA-CP组和CP组的各项临床指标均显著高于C组和RA组(P<0.05)。CP组和RA-CP组牙周组织总氧化剂状态(TOS)值明显高于RA组(P
Background: Chronic periodontitis (CP) and rheumatoid arthritis (RA) appear to share many pathologic features. Oxygen metabolism has an important role in the pathogenesis of both CP and RA. The aim of this study is to evaluate the relationship between these two chronic inflammatory diseases with regard to antioxidant and oxidant status.Methods: A total of 80 participants were divided into four groups of 20 each: group RA-CP (patients with RA and CP), group RA (periodontally healthy patients with RA), group CP (systemically healthy patients with CP), and group C (periodontally and systemically healthy volunteers) were included in the study. After assessment of periodontal measurements, gingival crevicular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum samples at -80 degrees C for the antioxidant/oxidant assay.Results: Although all clinical measurements in groups RA-CP and CP were statistically higher compared to those of C and RA groups (P0.05). GCF total oxidant status (TOS) values of CP and RA-CP groups were higher than those of the RA group (P