A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D3 Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness
A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D3 Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness
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DOI：
10.1210/jc.2010-0606
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发表时间：
2010-10-01
影响因子：
5.8
通讯作者：
Zhu, Haidong
中科院分区：
文献类型：
--
作者：
Dong, Yanbin;Stallmann-Jorgensen, Inger S.;Zhu, Haidong
内容：维生素D不足/缺乏症是常见的黑人youth.Objective：目的是确定25-羟基维生素D[25（OH）D]在响应2000 IU的维生素D补充随着时间的推移，以评估25（OH）D浓度和总体脂肪质量的双能X射线吸收法之间的关系，并通过测量25（OH）D浓度和总体脂肪质量之间的关系来确定25（OH）D浓度。并确定补充维生素D是否能改善通过脉搏波速度（PWV）测量的动脉硬度。设计：我们进行了一项随机、盲法、对照临床试验。设置和参与者：49名血压正常的黑人男孩和女孩，年龄16.3 ± 1.4岁，被随机分配到对照组或对照组。（400 IU/d; n = 24）或实验组（2000 IU/d; n = 25）。对照组在基线和第4、8和16周的血浆25（OH）D值分别为34.0 +/- 10.6、44.9 +/- 9.4、51.2 +/- 11.1和59.8 +/- 18.2 nmol/L;实验组分别为33.1 ± 8.7、55.0 ± 11.8、70.9 ± 22.0和85.7 ± 30.1 nmol/L。与对照组相比，实验组分别在第8和16周达到显著更高的25（OH）D浓度。偏相关分析表明，在基线时的总体脂量显着和25（OH）D浓度呈负相关，在响应2000-IU的补充随着时间的推移。此外，颈动脉-股动脉PWV较基线增加（5.38 +/- 0.53 m/sec）至试验后（5.71 +/- 0.75 m/sec），对照组（P = 0.016），而实验组颈-股动脉PWV较基线降低（5.41 +/- 0.73 m/sec）与后测（5.33 +/- 0.79 m/sec）比较（P = 0.031）。结论：每日补充2000 IU维生素D可有效改善黑人青年的维生素D状况，并对抗主动脉僵硬的进展。血浆25（OH）D浓度响应于2000 IU/d的补充是负调制肥胖。（临床内分泌代谢杂志95：4584-4591，2010）
Context: Vitamin D insufficiency/deficiency is commonly observed in black youth.Objective: The aim was to determine 25-hydroxyvitamin D[25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV).Design: We conducted a randomized, blinded, controlled clinical trial.Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 +/- 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25).Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 +/- 10.6, 44.9 +/- 9.4, 51.2 +/- 11.1, and 59.8 +/- 18.2 nmol/liter, respectively, for the control group; and 33.1 +/- 8.7, 55.0 +/- 11.8, 70.9 +/- 22.0, and 85.7 +/- 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 +/- 0.53 m/sec) to posttest (5.71 +/- 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 +/- 0.73 m/sec) to posttest (5.33 +/- 0.79 m/sec) (P = 0.031).Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity. (J Clin Endocrinol Metab 95: 4584-4591, 2010)