Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.
Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.
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DOI：
10.1016/j.celrep.2015.07.042
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发表时间：
2015-08-25
期刊：
影响因子：
8.8
通讯作者：
Neish AS
中科院分区：
文献类型：
--
作者：
Jones RM;Desai C;Darby TM;Luo L;Wolfarth AA;Scharer CD;Ardita CS;Reedy AR;Keebaugh ES;Neish AS
最佳肠道菌群影响后生动物宿主的许多有益过程。然而，在共生体诱导的宿主反应中介导和起作用的分子机制尚未完全表征。在这里，我们报道了小鼠和果蝇与乳酸菌接触时酶促产生的细胞ROS通过激活Nrf2应答细胞保护基因，对肠道上皮的外源性损伤具有有益的作用。这些数据表明，外源诱导的Nrf2通路作为原核共生体和真核宿主之间的信号通道参与。事实上，我们的数据表明，乳酸菌诱导上皮细胞氧化还原信号的能力是一种高度保守的致热适应，以促进细胞对外源生物刺激的调节。这些数据还强调了微生物群在真核细胞保护途径中的作用，并可能对益生菌群的表征具有重要意义。
An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in symbiont-induced host responses have not yet been fully characterized. Here, we report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes. These data show that the xenobiotic inducible Nrf2 pathway participates as a signaling conduit between the prokaryotic symbiont and the eukaryotic host. Indeed, our data imply that the capacity of lactobacilli to induce redox signaling in epithelial cells is a highly conserved hormetic adaptation to impel cellular conditioning to exogenous biotic stimuli. These data also highlight the role the microbiota plays in eukaryotic cytoprotective pathways, and may have significant implications in the characterization of a eubiotic microbiota.