The perceptual-mnemonic/feature conjunction model of perirhinal cortex function
The perceptual-mnemonic/feature conjunction model of perirhinal cortex function
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DOI：
10.1080/02724990544000004
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发表时间：
2005-07-01
期刊：
影响因子：
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通讯作者：
Saksida, LM
中科院分区：
文献类型：
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作者：
Bussey, TJ;Saksida, LM
嗅周皮层曾经被认为是“沉默皮层”，实际上被对学习和记忆的神经生物学感兴趣的研究人员所忽视。随着对与健忘症病例相关的脑损伤的研究，嗅周皮层现在被广泛认为是“内侧颞叶（MTL）记忆系统”的一部分。这个系统被认为在功能上或多或少是同质的，在陈述性记忆中有特殊的作用，对其他功能（如知觉）几乎没有贡献。在本文中，我们总结了另一种观点。首先，我们提出，假定的MTL系统的组成部分，如海马和嗅周皮质有不同的和分离的功能。第二，我们提供的证据表明，嗅周皮层在视觉辨别中的作用。此外，我们提出了一个特定的作用，在视觉歧视的边缘皮层：复杂的连接表示的视觉歧视问题的解决方案的贡献与高度的“功能模糊性”。这些建议构成了一个新的观点，嗅周皮层功能，一个不承担严格的模块化功能的枕-颞视觉流，但取代了这个想法的概念，一个分层的代表性连续。
The perirhinal cortex was once thought to be "silent cortex", virtually ignored by researchers interested in the neurobiology of learning and memory. Following studies of brain damage associated with cases of amnesia, perirhinal cortex is now widely regarded as part of a "medial temporal lobe (MTL) memory system". This system is thought to be more or less functionally homogeneous, having a special role in declarative memory, and making little or no contribution to other functions such as perception. In the present article, we summarize an alternative view. First, we propose that components of the putative MTL system such as the hippocampus and perirhinal cortex have distinct and dissociable functions. Second, we provide evidence that the perirhinal cortex has a role in visual discrimination. In addition, we propose a specific role for perirhinal cortex in visual discrimination: the contribution of complex conjunctive representations to the solution of visual discrimination problems with a high degree of "feature ambiguity". These proposals constitute a new view of perirhinal cortex function, one that does not assume strict modularity of function in the occipito-temporal visual stream, but replaces this idea with the notion of a hierarchical representational continuum.