EVIDENCE FOR OPIOID AND NON-OPIOID FORMS OF STIMULATION-PRODUCED ANALGESIA IN THE RAT
EVIDENCE FOR OPIOID AND NON-OPIOID FORMS OF STIMULATION-PRODUCED ANALGESIA IN THE RAT
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DOI：
10.1016/0006-8993(82)90255-4
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
LIEBESKIND, JC
中科院分区：
文献类型：
--
作者：
CANNON, JT;PRIETO, GJ;LIEBESKIND, JC
Stimulation-produced analgesia (SPA) elicited from 2 different midline regions of the midbrain of the rat are compared. Dorsal electrode placements were in the caudal periaqueductal gray matter while ventral placements lay within or subjacent to the dorsal raphen. SPA thresholds were measured by the tail-flick method both during and immediately after the period of brain stimulation. Thresholds were consistently higher in the post-stimulation test. SPA from dorsal and ventral regions differed in that post-stimulation analgesia was significantly more difficult to obtain in ventral than in dorsal regions, whereas during-stimulation analgesia did not vary as a function of electrode location. Although a continuous distribution of thresholds was seen for ventral placements, thresholds for dorsal placements tended to be either high or low on both during- and post-stimulation tests. Naloxone (0.01-10 mg/kg) reliably elevated SPA thresholds for ventral but not dorsal stimulation placements. Different substrates of SPA lie in close proximity to one another in the medial midbrain of the rat. This portion of the midbrain appears to mediate both opioid and nonopioid mechanisms of analgesia.
