Quantitation of regional cerebral blood flow with O-15-butanol and positron emission tomography in humans
Quantitation of regional cerebral blood flow with O-15-butanol and positron emission tomography in humans
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DOI：
10.1097/00004647-199607000-00015
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发表时间：
1996-07-01
影响因子：
6.3
通讯作者：
MullerGartner, HW
中科院分区：
文献类型：
--
作者：
Herzog, H;Seitz, RJ;MullerGartner, HW
我们描述的实施和验证相结合的动态放射自显影方法测量局部脑血流量（rCBF）与O-15-丁醇。根据以1 s速率采样的动脉血数据和累积超过100 s的脑放射性的列表模式数据，通过最小二乘拟合估计血液和组织曲线之间的时移、分散常数DC、分配系数p和CBF。使用拟合结果，对于单个40-s（放射自显影）O-15-丁醇摄取图像计算rCBF的逐像素参数化。27名健康受试者的平均总体CBF为49 +/- 8 ml 100 g（-1）min（-1）。灰色和白色物质的rCBF分别为83 +/- 20和16 +/- 3 ml 100 g（-1）min（-1），两个室中相应的分配系数p分别为0.77 +/- 0.18和0.77 +/- 0.29 ml/g。定量图像导致灰质rCBF显著高于放射自显影图像。
We describe the implementation and validation of a combined dynamic-autoradiographic approach for measuring the regional cerebral blood flow (rCBF) with O-15-butanol. From arterial blood data sampled at a rate of 1 s and list mode data of the cerebral radioactivity accumulated over 100 s, the time shift between blood and tissue curves, the dispersion constant DC, the partition coefficient p, and the CBF were estimated by least squares fitting, Using the fit results, a pixel-by-pixel parametrization of rCBF was computed for a single 40-s (autoradiographic) O-15-butanol uptake image. The mean global CBF found in 27 healthy subjects was 49 +/- 8 ml 100 g(-1) min(-1). Gray and white matter rCBF were 83 +/- 20 and 16 +/- 3 ml 100 g(-1) min(-1), respectively, with a corresponding partition coefficient p of 0.77 +/- 0.18 and 0.77 +/- 0.29 ml/g in both compartments. The quantitative images resulted in a significantly higher gray matter rCBF than the autoradiographic images.