Regulation of heme biosynthesis and transport in metazoa.
Regulation of heme biosynthesis and transport in metazoa.
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后生动物血红素生物合成和运输的调节。
DOI：
10.1007/s11427-015-4885-5
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Chen Caiyong
中科院分区：
文献类型：
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作者：
Sun Fengxiu;Cheng Yongjiao;Chen Caiyong
血红素是一种含铁的四吡罗，在调节多种生物过程中起关键作用，包括氧和电子传递、气体传感、信号转导、生物钟和microRNA加工。大多数后生动物细胞通过由八种酶催化反应组成的保守途径合成血红素。血红素也可以从食物或细胞外环境中获得。细胞血红素稳态是通过合成、运输和降解的协调调节来维持的。本文综述了后生动物中血红素的合成和运输的最新知识，并强调了这些途径的调节的最新进展。
Heme is an iron-containing tetrapyrrole that plays a critical role in regulating a variety of biological processes including oxygen and electron transport, gas sensing, signal transduction, biological clock, and microRNA processing. Most metazoan cells synthesize heme via a conserved pathway comprised of eight enzyme-catalyzed reactions. Heme can also be acquired from food or extracellular environment. Cellular heme homeostasis is maintained through the coordinated regulation of synthesis, transport, and degradation. This review presents the current knowledge of the synthesis and transport of heme in metazoans and highlights recent advances in the regulation of these pathways.