Multilayered hydrogel coatings covalently-linked to glass surfaces showing a potential to mimic mucosal tissues
Multilayered hydrogel coatings covalently-linked to glass surfaces showing a potential to mimic mucosal tissues
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DOI：
10.1039/b918007a
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发表时间：
2010-01-01
期刊：
影响因子：
3.4
通讯作者：
Khutoryanskiy, Vitaliy V.
中科院分区：
文献类型：
--
作者：
Khutoryanskaya, Olga V.;Potgieter, Mader;Khutoryanskiy, Vitaliy V.
通过聚丙烯酸和甲基纤维素形成的氢键互聚物复合物的逐层沉积，可以在载玻片表面形成多层水凝胶涂层。用（3-氨基丙基）三乙氧基硅烷对玻璃表面进行化学改性，随后通过热处理进行逐层沉积和互聚物复合物的交联，从而可以制造出不可从基材上分离的超薄水凝胶涂层。这些涂层的厚度与沉积循环次数和交联条件直接相关。观察到水凝胶膨胀特性对样品厚度的异常依赖性，并且可以通过二维和三维网络之间的逐渐过渡来解释。水凝胶表现出 pH 响应性溶胀行为，在 pH > 6.0 时实现更高的溶胀度。这些涂层可用作模型基材来研究药物片剂的粘合特性，并且可以潜在地模拟粘膜粘合剂从猪颊粘膜脱离时观察到的总粘附功，但无法表现出相同的脱离曲线。
Multilayered hydrogel coatings can be developed on the surface of glass slides via layer-by-layer deposition of hydrogen-bonded interpolymer complexes formed by poly(acrylic acid) and methylcellulose. Chemical modification of the glass surface with (3-aminopropyl)triethoxysilane with subsequent layer-by-layer deposition and cross-linking of interpolymer complexes by thermal treatment allows fabrication of ultrathin hydrogel coatings, not detachable from the substrate. The thickness of these coatings is directly related to the number of deposition cycles and cross-linking conditions. An unusual dependence of the hydrogel swelling properties on the sample thickness is observed and can be interpreted by gradual transitions between two-and three-dimensional networks. The hydrogels exhibit pH-responsive swelling behaviour, achieving higher swelling degrees at pH > 6.0. These coatings can be used as model substrates to study the adhesive properties of pharmaceutical tablets and can potentially mimic the total work of adhesion observed for the detachment of mucoadhesives from porcine buccal mucosa but fail to exhibit identical detachment profiles.