Graft-Versus-Host Disease
Graft-Versus-Host Disease
复制标题
移植物抗宿主病
DOI：
10.1007/978-3-030-04489-3_18
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Arun D. Singh
中科院分区：
文献类型：
--
作者：
E. Espana;Lauren J. Jeang;Arun D. Singh
移植物抗宿主病（GVHD）是骨髓移植后一种严重且具有破坏性的并发症。急性或慢性全身性GVHD可能是致命的，两种类型的GVHD都会造成不同器官和组织的严重损害。眼部受累，无论是急性还是慢性，可能从轻微到严重不等。慢性眼部 GVHD 是 GVHD 最常见的形式，主要影响眼表成分：泪腺、睑板腺、角膜和结膜，类似于其他免疫介导的眼表炎症性疾病。眼部 GVHD 的长期治疗仍然具有挑战性，需要采取多学科方法，其中需要药物和手术选择。通常使用全身免疫抑制、眼部润滑剂、局部类固醇和局部环孢素。对于中度和重度眼部 GVHD 更积极的治疗干预措施包括使用血清滴眼液和巩膜隐形眼镜。在本章中，我们回顾了眼 GVHD 的机制、临床表现和治疗。
Graft-versus-host disease (GVHD) is a serious and devastating complication following bone marrow transplantation. Acute or chronic systemic GVHD can be lethal, and severe damage of different organs and tissues occurs with both types of GVHD. Ocular involvement, either in an acute or chronic presentation, may range from mild to severe. Chronic ocular GVHD, the most common form of GVHD, affects mainly the ocular surface components: lacrimal gland, meibomian glands, cornea, and conjunctiva, mimicking other immunologically mediated inflammatory diseases of the ocular surface. The long-term treatment of ocular GVHD continues to be challenging and involves a multidisciplinary approach where medical and surgical options are necessary. Systemic immunosuppression, ocular lubricants, topical steroids, and topical cyclosporine are commonly prescribed. More aggressive therapeutic interventions for moderate and severe ocular GVHD include the use of serum eye drops and scleral contact lenses. In this chapter, we review the mechanisms, clinical findings, and treatment of ocular GVHD.
影响因子：
4.4
作者：
Ogawa, Y;Kodama, H;Kuwana, M
通讯作者：
Kuwana, M
影响因子：
4.6
作者：
He J;Ogawa Y;Mukai S;Saijo-Ban Y;Kamoi M;Uchino M;Yamane M;Ozawa N;Fukui M;Mori T;Okamoto S;Tsubota K
通讯作者：
Tsubota K