Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age
Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age
复制标题
DOI：
10.1067/mpd.2001.112895
复制
发表时间：
2001-05-01
影响因子：
5.1
通讯作者：
Lönnerdal, B
中科院分区：
文献类型：
--
作者：
Domellöf, M;Cohen, RJ;Lönnerdal, B
目的：目的是研究补充铁剂对 2 个不同人群的血红蛋白和铁状态的影响。 研究设计：在一项随机、安慰剂对照、隐蔽临床试验中，我们将足月瑞典 (n = 101) 和洪都拉斯 (n = 131) 婴儿在 4 个月大时分为 3 组：(1) 铁补充剂，1 mg/kg/d，从 4 到 9 个月，(2) 安慰剂，4 到 9 个月。 6 个月，铁剂，6 至 9 个月，(3) 安慰剂，4 至 9 个月。所有婴儿均纯母乳喂养至 6 个月，部分至 9 个月。结果：从 4 至 6 个月，铁（第 1 组与第 2 + 3 组）对两个人群的血红蛋白、铁蛋白和锌原卟啉的影响显着且相似。从 6 到 9 个月，除血红蛋白外，两个地点的所有铁状态变量的效果（第 2 组与第 3 组）均显着且相似，血红蛋白仅在洪都拉斯有显着效果。在洪都拉斯，安慰剂组 9 个月时缺铁性贫血的患病率为 29%，补充剂组为 9%。在瑞典，铁补充剂在 9 个月时并没有降低本来就很低的缺铁性贫血患病率（
Objective: The objective was to study the effects of iron supplementation on hemoglobin and iron status in 2 different populations.Study design: In a randomized, placebo-controlled, masked clinical trial, we assigned term Swedish (n = 101) and Honduran (n = 131) infants to 3 groups at 4 months of age: (1) iron supplements, 1 mg/kg/d, from 4 to 9 months, (2) placebo, 4 to 6 months and iron, 6 to 9 months, and (3) placebo, 4 to 9 months. All infants were breast-fed exclusively to 6 months and partially to 9 months.Results: From 4 to 6 months, the effect of iron (group 1 vs 2 + 3) was significant and similar in both populations for hemoglobin, ferritin, and zinc protoporphyrin. From 6 to 9 months, the effect (group 2 vs group 3) was significant and similar at both sites for all iron status variables except hemoglobin, for which there was a significant effect only in Honduras. In Honduras, the prevalence of iron deficiency anemia at 9 months was 29% in the placebo group and 9% in the supplemented groups. In Sweden, iron supplements caused no reduction in the already low prevalence of iron deficiency anemia at 9 months (