Lung Injury from Oxygen in Lambs: The Role of Artificial Ventilation
Lung Injury from Oxygen in Lambs: The Role of Artificial Ventilation
复制标题
羔羊因氧气引起的肺损伤：人工通气的作用
作者：
R. Delemos;J. Wolfsdorf;R. Nachman;A. Block;G. Leiby;H. Wilkinson;T. Allen;J. Haller;W. Morgan;M. Avery
一到两周大的羔羊呼吸80%到100%的氧气，两到四天后就会死亡。人工呼吸机不会加重或显著改善肺反应。在相同的时间段内，在呼吸器上使用空气通风的羔羊没有明显的肺损伤。氧处理羔羊的死亡原因是肺损伤，以水肿为特征。对切除的肺的研究表明，病变呈斑点状，肺的正常外观部分正常可膨胀，肺表面活性物质没有明显变化。给出了几种评估力学错位的方法。
Eighty to 100 per cent oxygen, breathed by lambs one or two weeks of age, is lethal after two to four days. Artificial ventilation did not aggravate or significantly ameliorate the pulmonary response. Lambs ventilated with air on respirators for comparable periods had no significant pulmonary damage. The cause of death of the oxygen-treated lambs was the pulmonary injury, characterized by edema. Studies of the excised lungs showed that the lesion was spotty, that the normal-appearing portions of the lung were normally distensible, and no significant alterations in pulmonary surfactant occurred. Several methods of assessment of the mechanical derangements are presented.