Unique CD8+ T cell‐rich lymphoid aggregates in human uterine endometrium
Unique CD8+ T cell‐rich lymphoid aggregates in human uterine endometrium
复制标题
人子宫内膜中独特的富含 CD8+ T 细胞的淋巴聚集体
DOI：
10.1002/jlb.61.4.427
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发表时间：
1997
影响因子：
5.5
通讯作者：
C. Wira
中科院分区：
文献类型：
--
作者：
G. Yeaman;P. Guyre;M. Fanger;J. Collins;H. White;W. Rathbun;K. Orndorff;Jorge L. Gonzalez;J. Stern;C. Wira
利用激光共聚焦扫描显微镜的活组织切片，我们已经证明了有组织的淋巴聚集体（LA），具有独特的结构，在子宫内膜的基底层。这些LA由被更多T细胞包围的B细胞核心和单核细胞/巨噬细胞外晕组成。LA中的T细胞几乎完全是CD 8 + CD 4-。这些CD 8 + LA，就其T细胞和B细胞组分而言，在月经周期的早期增殖阶段较小或不存在，在周期中期和分泌期尺寸显著较大，在绝经后女性中不存在，表明其发育受到生殖影响。这一新发现的月经周期依赖性，表型独特，有组织的免疫细胞结构可能导致新的见解的机制，子宫内膜接受半同种异体移植物，同时提供抵抗感染性生物体。J. Leukoc. 61：427-435; 1997.
Using confocal scanning laser microscopy of viable tissue sections, we have demonstrated organized lymphoid aggregates (LA), that have a unique structure, in the stratum basalis of uterine endometrium. These LA consist of a core of B cells surrounded by more numerous T cells and an outer halo of monocytes/macrophages. The T cells in the LA were almost exclusively CD8+CD4‐. These CD8+ LA, in terms of both their T cell and B cell components, were either small or absent during the early proliferative stage of the menstrual cycle, significantly larger in size at mid‐cycle and during the secretory phase, and absent in post‐menopausal women, suggesting that their development is hormonally influenced. This new finding of a menstrual cycle‐dependent, phenotypically unique, organized immune cell structure may lead to new insights into the mechanisms by which the endometrium accepts a semiallogeneic graft while providing resistance to infectious organisms. J. Leukoc. Biol. 61: 427–435; 1997.
整个月经周期中人类子宫内膜淋巴细胞的增殖活性。
DOI：
10.1210/jcem-70-2-437
发表时间：
1990
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Tabibzadeh,S
通讯作者：
Tabibzadeh,S
人类子宫内膜中 T 细胞激活和潜在细胞因子作用的证据。
DOI：
10.1210/jcem-71-3-645
发表时间：
1990
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Tabibzadeh,S
通讯作者：
Tabibzadeh,S