Does the addition of information on genotype improve prediction of the risk of melanoma and nonmelanoma skin cancer beyond that obtained from skin phenotype?
Does the addition of information on genotype improve prediction of the risk of melanoma and nonmelanoma skin cancer beyond that obtained from skin phenotype?
复制标题
DOI：
10.1093/aje/kwh120
复制
发表时间：
2004-05-01
影响因子：
5
通讯作者：
Sale, MM
中科院分区：
文献类型：
--
作者：
Dwyer, T;Stankovich, JM;Sale, MM
作者量化了在预测皮肤恶性黑色素瘤、基底细胞癌和皮肤鳞状细胞癌方面的改善，这是通过1998-1999年澳大利亚塔斯马尼亚的一项基于人群的病例对照研究中关于黑素皮质素-1受体基因(MC1R)常见变异的信息而实现的。用分光光度法检测上臂内侧黑素密度。DNA样本进行了5种MC1R变异体的基因分型：Val60Leu、Asp84Glu、Arg151Cys、Arg160Trp和Asp294His。在对照组(n=267)中，变异携带者与非携带者相比，差异有统计学意义(P
The authors quantified improvement in predicting cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin made possible by information on common variants of the melanocortin-1 receptor gene (MC1R) in a 1998-1999 population-based case-control study of subjects aged 20-59 years of northern European ancestry in Tasmania, Australia. Melanin density at the upper inner arm was estimated by spectrophotometry. DNA samples were genotyped for five MC1R variants: Val60Leu, Asp84Glu, Arg151Cys, Arg160Trp, and Asp294His. Among controls (n=267), variant carriers, versus noncarriers, had lower (p