Simultaneous perfusion and blood-oxygenation-level-dependent measurements using single-shot interleaved z-shim echo-planar imaging.
Simultaneous perfusion and blood-oxygenation-level-dependent measurements using single-shot interleaved z-shim echo-planar imaging.
复制标题
使用单次交错 z 垫片回波平面成像同时进行灌注和血氧水平依赖性测量。
DOI：
10.1002/mrm.20431
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Stern,Emily
中科院分区：
文献类型：
--
作者：
Yang,Yihong;Gu,Hong;Silbersweig,DavidA;Stern,Emily
Single‐shot interleavedz‐shim EPI (SSIZS‐EPI) was extended to a simultaneous perfusion and blood‐oxygenation‐level‐dependent (BOLD) imaging technique that reduces susceptibility‐induced signal loss while preserving rapid image acquisition. Experiments on human brains showed that images acquired with this technique had improved signal‐to‐noise ratio in the inferior prefrontal, meso‐, and lateral–temporal lobes compared with a conventional EPI. Perfusion maps obtained from the SSIZS‐EPI images at resting state illustrated substantial signal recovery in these brain areas. Perfusion and BOLD images collected with a sensorimotor paradigm demonstrated the feasibility of the technique to simultaneously measure cerebral blood flow and blood oxygenation signals associated with brain activation. Functional experiments with a neuropsychiatric paradigm showed increased brain activities in the periamygdalar regions in both perfusion and BOLD maps, consistent with a previous H215O PET study. The proposed technique, with its advantages of reducing susceptibility artifacts and fast scanning speed, would be useful for obtaining more reliable measurements of functional signals, particularly in the brain regions with field inhomogeneities. Magn Reson Med 53:1207–1211, 2005. Published 2005 Wiley‐Liss, Inc.
