PATHOLOGIC EFFECTS OF ELIXIR OF SULFANILAMIDE (DIETHYLENE GLYCOL) POISONING: A CLINICAL AND EXPERIMENTAL CORRELATION: FINAL REPORT
PATHOLOGIC EFFECTS OF ELIXIR OF SULFANILAMIDE (DIETHYLENE GLYCOL) POISONING: A CLINICAL AND EXPERIMENTAL CORRELATION: FINAL REPORT
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磺胺（二甘醇）中毒酏剂的病理效应：临床和实验相关性：最终报告
DOI：
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发表时间：
1938
期刊：
影响因子：
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通讯作者：
P. Cannon
中科院分区：
文献类型：
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作者：
E. Geiling;P. Cannon
在1937年9月和10月，至少有761人在不同的地方死于磺胺-马森吉尔药剂中毒。M. A.化学实验室发现，这种制剂基本上是10%的磺胺在约72%的二甘醇中的溶液，加上一些着色剂和调味剂。没有汞等污染物，其影响可能类似于长生不老药产生的临床症状。显然，这种产品的制造商没有意识到它可能的毒性，并在没有对动物进行充分测试的情况下自由销售。它没有提交给美国医学协会药学和化学理事会，美国农业部食品和药物管理局也不知道它的组成。报纸报道的死亡人数从这个“新的
During the months of September and October 1937 at least seventy-six1human beings in various localities died as a result of poisoning by Elixir of Sulfanilamide-Massengill.2By analysis,3the A. M. A. Chemical Laboratory found this preparation to be essentially a 10 per cent solution of sulfanilamide in about 72 per cent diethylene glycol, together with some coloring and flavoring agents. There were no contaminants such as mercury, the effects of which might have resembled the clinical symptoms produced by the elixir. Apparently the makers of this product were unaware of its possible toxicity and distributed it freely without having tested it adequately on animals. It had not been submitted to the Council on Pharmacy and Chemistry of the American Medical Association nor did the Food and Drug Administration of the United States Department of Agriculture know of its composition. Newspaper reports of deaths from this "new