Association of hepatitis viruses with hepatocellular carcinoma in Thailand
Association of hepatitis viruses with hepatocellular carcinoma in Thailand
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DOI：
10.1007/s005350050248
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发表时间：
1999-04-01
影响因子：
6.3
通讯作者：
Poovorawan, Y
中科院分区：
文献类型：
--
作者：
Tangkijvanich, P;Hirsch, P;Poovorawan, Y
肝细胞癌（HCC）是泰国男性中最常见的恶性肿瘤，泰国是乙型肝炎病毒（HBV）感染的流行地区。各种危险因素与HCC的发生有关，其中包括暴露于某些毒素，感染肝炎病毒，特别是乙型肝炎病毒，以及在非乙型肝炎病毒感染流行地区感染丙型肝炎病毒。为了研究肝炎病毒与HCC的关系，本研究小组调查了101例临床（主要通过甲胎蛋白水平）和/或组织学诊断为肝细胞癌的患者。我们还检查了200名自愿献血者作为对照。所有受试者均接受乙型肝炎表面抗原（HBsAg）和抗HCV血清学检测，采用聚合酶链反应（PCR）检测HBV和TT病毒（TTV） DNA，逆转录(RT)-PCR检测HCV RNA和HGV RNA。在HCC患者中，HBV的患病率为65%，是HCV的4倍（17%），HGV的10倍（6%），TTV的7倍（9%）。在对照组中，HBV的患病率为0.5%；HCV为0.5%；HGV占5%；电视占7%。这些发现证实，乙型肝炎病毒与泰国人群中肝细胞癌的发展有关，其中慢性肝炎和肝硬化的病史也经常出现。
Hepatocellular carcinoma (HCC) represents the most common form of malignant tumor among males in Thailand, an area endemic for hepatitis B virus (HBV) infection. Various risk factors have been associated with the development of HCC, among them exposure to certain toxins, and infection with hepatitis viruses, in particular HBV, as well as HCV in areas nonendemic for HBV infection. To examine the association of hepatitis viruses with HCC, our group investigated 101 patients who had been clinically, mainly via alpha fetoprotein level, and/or histologically diagnosed with hepatocellular carcinoma. We also examined 200 voluntary blood donors as controls. All subjects underwent serological tests for the presence of hepatitis B surface antigen (HBsAg) and anti-HCV with polymerase chain reaction (PCR) used for the detection of HBV and TT virus (TTV) DNA, and reverse transcription (RT)-PCR for the detection of HCV RNA and HGV RNA. Besides showing a clear preponderance of HCC among males, with a peak incidence the age group 51-70 years, the results obtained in the HCC patients demonstrated that the prevalence of HBV was 65%, four times that of HCV (17%), ten times that of HGV (6%), and seven times that of TTV (9%), In the controls, the prevalence of HBV was 0.5%; that of HCV, 0.5%; that of HGV, 5%; and that of TTV, 7%. These findings confirmed that hepatitis B virus was associated with the development of hepatocellular carcinoma among the Thai population, among whom case histories of chronic hepatitis and cirrhosis have also been encountered quits frequently.