Urinary prostasin excretion is associated with adiposity in nonhypertensive African-American adolescents.
Urinary prostasin excretion is associated with adiposity in nonhypertensive African-American adolescents.
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DOI：
10.1038/pr.2013.81
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发表时间：
2013-08
影响因子：
3.6
通讯作者：
Dong, Yanbin
中科院分区：
文献类型：
--
作者：
Guo, De-huang;Parikh, Samip J.;Chao, Julie;Pollock, Norman K.;Wang, Xiaoling;Snieder, Harold;Navis, Gerjan;Wilson, James G.;Bhagatwala, Jigar;Zhu, Haidong;Dong, Yanbin
Metabolic abnormalities in obesity can overstimulate the renal epithelial sodium channel (ENaC) and subsequently lead to blood pressure (BP) elevation. Prostasin, a membrane-bound/secretive serine protease, is thought to activate ENaC via the proteolytic cleavage of the channel. Our specific aim was to explore whether there is a relationship between adiposity and urinary prostasin excretion at the population level. In 271 African-American adolescents, urinary prostasin concentrations were determined by enzyme-linked immunosorbent assay and normalized by urinary creatinine. Urinary prostasin excretion increased in the over- weight/obese group (n = 110, 38.2 ± 4.0 ng/mg) vs. the normal-weight group (n = 161, 20.7 ± 1.2 ng/mg, P = 0.03). Urinary prostasin excretion was significantly correlated with BMI percentiles (r = 0.14, P = 0.02), waist circumference (r = 0.13, P = 0.05), total body fat mass (r = 0.20, P < 0.01), and percentage body fat (r = 0.23, P < 0.01). Urinary prostasin excretion was also correlated with plasma aldosterone (r = 0.11, P = 0.05) and systolic BP (SBP; r = 0.15, P = 0.02), but the significances disappeared after adjustment of any of the adiposity variables. Our data for the first time suggest that adiposity plays a role in urinary prostasin excretion, and its associations with aldosterone and BP appear to be modulated by adiposity. Whether urinary prostasin excretion is a biomarker/mechanism underlying obesity-related hypertension deserves further investigations.
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影响因子：
2.8
作者：
Chen, LM;Zhang, XC;Chai, KX
通讯作者：
Chai, KX
影响因子：
8.3
作者：
Saha, C;Eckert, GJ;Pratt, JH
通讯作者：
Pratt, JH
影响因子：
8.3
作者：
Olivieri, O;Castagna, A;Righetti, PG
通讯作者：
Righetti, PG
DOI：
10.1152/ajprenal.00047.2006
发表时间：
2006-09-01
影响因子：
4.2
作者：
Chen, Li-Mei;Wang, Cindy;Chai, Karl X.
通讯作者：
Chai, Karl X.
影响因子：
19.6
作者：
Wakida, N.;Kitamura, K.;Tomita, K.
通讯作者：
Tomita, K.