Midlife cardiovascular fitness and dementia A 44-year longitudinal population study in women
Midlife cardiovascular fitness and dementia A 44-year longitudinal population study in women
复制标题
DOI：
10.1212/wnl.0000000000005290
复制
发表时间：
2018-04-10
期刊：
影响因子：
9.9
通讯作者：
Skoog, Ingmar
中科院分区：
文献类型：
--
作者：
Horder, Helena;Johansson, Lena;Skoog, Ingmar
Objectives探讨中年期心血管健康是否与随访44 years.MethodsA人群为基础的样本1，462名38 ~ 60岁的女性痴呆风险降低有关。其中，一个系统的子样本，包括191名妇女完成了逐步增加的最大测力计骑自行车测试，以评估心血管健康。随后在1974年、1980年、1992年、2000年、2005年和2009年进行了痴呆症发病率的检查。根据DSM-III-R标准，根据神经精神检查，知情人访谈，医院记录和截至2012年的注册数据的信息诊断痴呆症。考克斯回归进行调整的社会经济，生活方式和医疗confiers.ResultsCompared中等健身，调整后的风险比为全因痴呆症在44年的随访中为0.12（95%置信区间[CI] 0.03-0.54）之间的高健身和1.41（95%CI 0.72-2.79）之间的低健身。高健身延迟痴呆发作的年龄由9.5年和痴呆发作的时间由5年相比，中等fitness.ConclusionsAmong Swedish women，在中年高心血管健身与随后的痴呆症的风险降低。促进高心血管健康可能包括在减轻或预防痴呆症的策略中。研究结果不是因果关系，未来的研究需要关注改善的健康是否会对痴呆风险产生积极影响，以及在生命过程中何时高心血管健康是最重要的。
ObjectiveTo investigate whether greater cardiovascular fitness in midlife is associated with decreased dementia risk in women followed up for 44 years.MethodsA population-based sample of 1,462 women 38 to 60 years of age was examined in 1968. Of these, a systematic subsample comprising 191 women completed a stepwise-increased maximal ergometer cycling test to evaluate cardiovascular fitness. Subsequent examinations of dementia incidence were done in 1974, 1980, 1992, 2000, 2005, and 2009. Dementia was diagnosed according to DSM-III-R criteria on the basis of information from neuropsychiatric examinations, informant interviews, hospital records, and registry data up to 2012. Cox regressions were performed with adjustment for socioeconomic, lifestyle, and medical confounders.ResultsCompared with medium fitness, the adjusted hazard ratio for all-cause dementia during the 44-year follow-up was 0.12 (95% confidence interval [CI] 0.03-0.54) among those with high fitness and 1.41 (95% CI 0.72-2.79) among those with low fitness. High fitness delayed age at dementia onset by 9.5 years and time to dementia onset by 5 years compared to medium fitness.ConclusionsAmong Swedish women, a high cardiovascular fitness in midlife was associated with a decreased risk of subsequent dementia. Promotion of a high cardiovascular fitness may be included in strategies to mitigate or prevent dementia. Findings are not causal, and future research needs to focus on whether improved fitness could have positive effects on dementia risk and when during the life course a high cardiovascular fitness is most important.