Biphasic calcium phosphate bioceramics: preparation, properties and applications
Biphasic calcium phosphate bioceramics: preparation, properties and applications
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DOI：
10.1023/a:1022872421333
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发表时间：
2003-03-01
影响因子：
3.7
通讯作者：
Legeros, JP
中科院分区：
文献类型：
--
作者：
Legeros, RZ;Lin, S;Legeros, JP
双相磷酸钙（BCP）生物陶瓷属于一组骨替代生物材料，由不同HA/β-TCP比例的羟基磷灰石（HA）Ca-10（PO 4）（6）（OH）（2）和β-磷酸三钙（β-TCP）Ca-3（PO 4）（2）的紧密混合物组成。当合成或生物缺钙磷灰石在700摄氏度或以上的温度下烧结时，就会得到BCP。缺钙取决于制备方法（沉淀、水解或机械混合），包括反应pH值和温度。HA/β-TCP的比例取决于未烧结磷灰石的缺钙量（缺钙量越大，比例越低）和烧结温度。BCP生物陶瓷与其医疗应用相关的性能包括：大孔隙率、微孔率、抗压强度、生物活性（与在体外和体内陶瓷表面形成碳酸羟基磷灰石相关）、溶解性和骨传导性。由于β-TCP组分的优先溶解，生物活性与HA/β-TCP比率成反比。因此，BCP生物陶瓷的生物活性可以通过控制BCP的组成（HA/β-TCP比率）和/或结晶度来控制。目前，BCP生物陶瓷被推荐用作骨科和牙科应用中自体骨的替代品或添加剂。它以颗粒、块、针对特定应用的定制设计以及聚合物载体中的可注射生物材料的形式提供。BCP陶瓷也可用作喷砂磨料，用于喷砂以改性植入物基质表面。探索性研究表明，BCP陶瓷作为组织工程支架、药物缓释系统和生长因子载体具有潜在的应用前景。(C)2003 Kluwer Academic Publishers.
Biphasic calcium phosphate (BCP) bioceramics belong to a group of bone substitute biomaterials that consist of an intimate mixture of hydroxyapatite (HA), Ca-10(PO4)(6)(OH)(2), and beta-tricalcium phosphate (beta-TCP), Ca-3(PO4)(2), of varying HA/beta-TCP ratios. BCP is obtained when a synthetic or biologic calcium-deficient apatite is sintered at temperatures at and above 700degreesC. Calcium deficiency depends on the method of preparation (precipitation, hydrolysis or mechanical mixture) including reaction pH and temperature. The HA/beta-TCP ratio is determined by the calcium deficiency of the unsintered apatite (the higher the deficiency, the lower the ratio) and the sintering temperature.Properties of BCP bioceramics relating to their medical applications include: macroporosity, microporosity, compressive strength, bioreactivity (associated with formation of carbonate hydroxyapatite on ceramic surfaces in vitro and in vivo), dissolution, and osteoconductivity. Due to the preferential dissolution of the beta-TCP component, the bioreactivity is inversely proportional to the HA/beta-TCP ratio. Hence, the bioreactivity of BCP bioceramics can be controled by manipulating the composition (HA/beta-TCP ratio) and/or the crystallinity of the BCP.Currently, BCP bioceramics is recommended for use as an alternative or additive to autogeneous bone for orthopedic and dental applications. It is available in the form of particulates, blocks, customized designs for specific applications and as an injectible biomaterial in a polymer carrier. BCP ceramic can be used also as grit-blasting abrasive for grit-blasting to modify implant substrate surfaces. Exploratory studies demonstrate the potential uses of BCP ceramic as scaffold for tissue engineering, drug delivery system and carrier of growth factors. (C) 2003 Kluwer Academic Publishers.