Redox imbalance stress in diabetes mellitus: Role of the polyol pathway.
Redox imbalance stress in diabetes mellitus: Role of the polyol pathway.
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DOI：
10.1002/ame2.12001
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发表时间：
2018-03
影响因子：
3.7
通讯作者：
Yan LJ
中科院分区：
文献类型：
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作者：
Yan LJ
在糖尿病中，多元醇途径高度活跃，消耗体内约30%的葡萄糖。该途径包含2个反应，分别由醛糖还原酶（AR）和山梨醇脱氢酶催化。AR以NADPH为代价将葡萄糖还原为山梨糖醇，而山梨糖醇脱氢酶以NAD +为代价将山梨糖醇转化为果糖，从而产生NADH。NADPH的消耗、山梨醇的积累以及果糖和NADH的产生都与糖尿病及其并发症的发病机制有关。本文综述了该通路在糖尿病中NADH/NAD +氧化还原失衡和氧化应激中的作用。还讨论了使用烟酰胺核苷恢复氧化还原平衡作为对抗糖尿病的方法的潜在干预。
In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) and sorbitol dehydrogenase, respectively. AR reduces glucose to sorbitol at the expense of NADPH, while sorbitol dehydrogenase converts sorbitol to fructose at the expense of NAD +, leading to NADH production. Consumption of NADPH, accumulation of sorbitol, and generation of fructose and NADH have all been implicated in the pathogenesis of diabetes and its complications. In this review, the roles of this pathway in NADH/NAD + redox imbalance stress and oxidative stress in diabetes are highlighted. A potential intervention using nicotinamide riboside to restore redox balance as an approach to fighting diabetes is also discussed.