RISK FOR READING-DISABILITY AS A FUNCTION OF PARENTAL HISTORY IN 3 FAMILY STUDIES
RISK FOR READING-DISABILITY AS A FUNCTION OF PARENTAL HISTORY IN 3 FAMILY STUDIES
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DOI：
10.1007/bf00354958
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发表时间：
1991-12-01
影响因子：
2.5
通讯作者：
DEFRIES, JC
中科院分区：
文献类型：
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作者：
GILGER, JW;PENNINGTON, BF;DEFRIES, JC
逆贝叶斯分析应用于数据的阅读残疾的三个大家庭的研究，估计后验概率，后代将受到影响，鉴于父母报告的历史学习问题。其他地方提供的先前分析（彭宁顿等人，1990），表明这三项研究中的家庭传播与主基因或多基因影响一致。本文给出了男女性别比为3.5：1和1：1的后验概率，人口发病率估计为0.05和0.10。结果表明，后代的风险率显着升高，如果父母报告的RD的历史。具体来说，当有一个受影响的父母时，后代的风险比人口预期增加2到80倍。虽然各研究的后验概率和相对风险率相当相似，但也存在一些差异，这可能反映了这些家庭中不同的遗传机制。本研究得出结论，RD父母的绝对和相对风险均充分增加，以保证将家族史作为临床评价的一个组成部分。从这些结果中还可以明显看出，在获得家族史时，考虑家族中遗传传播的表观模式可以提供关于后代风险的更好信息。
Inverse Bayesian analyses were applied to data from three large family studies of reading disability to estimate the posterior probability that an offspring will be affected, given that a parent reported a history of learning problems. Prior analyses presented elsewhere (Pennington et al., 1990), suggest that family transmission in these three studies is consistent with major gene or polygene influence. Posterior probability rates are presented in this paper for male to female sex ratios of 3.5:1 and 1:1, with population incidences estimated at 0.05 and 0.10. Results indicate that offspring risk rates are significantly elevated if a parent reports a history of RD. Specifically, an offspring's risk was increased 2 to 80 times over population expectancies when there was an affected parent. While the posterior probabilities and relative risk rates were fairly similar across studies, there was also some variation, which may reflect the different genetic mechanisms operating in these families. This study concludes that both absolute and relative risks are sufficiently increased in families with RD parents to warrant use of family history as a component in clinical evaluation. It is also evident from these results that consideration of the apparent mode of genetic transmission in families may provide even better information as to offspring risk, when family history is obtained.