Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.
Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.
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DOI：
10.1146/annurev-biophys-101211-113227
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发表时间：
2012
影响因子：
12.4
通讯作者：
Booth IR
中科院分区：
文献类型：
--
作者：
Naismith JH;Booth IR
机械传感通道的发现改变了我们对细菌生理学的理解。机械敏感的小电导通道(MSCs)可能是这些通道中研究最深入的。MSCs至少有两种状态：闭合状态，不允许溶质流出细胞质；打开状态，允许溶剂和溶质快速外流。适当地打开或关闭通道(门控)的能力对细菌的生存至关重要。我们简要回顾了导致骨髓间充质干细胞分离和鉴定的科学。我们专注于通道的结构-功能关系，特别是了解通道门控的结构和生化方法。我们强调了为理解MSCs门控而开发的各种模型之间令人不安的差异。
The discovery of mechanosensing channels has changed our understanding of bacterial physiology. The mechanosensitive channel of small conductance (MscS) is perhaps the most intensively studied of these channels. MscS has at least two states: closed, which does not allow solutes to exit the cytoplasm, and open, which allows rapid efflux of solvent and solutes. The ability to appropriately open or close the channel (gating) is critical to bacterial survival. We briefly review the science that led to the isolation and identification of MscS. We concentrate on the structure-function relationship of the channel, in particular the structural and biochemical approaches to understanding channel gating. We highlight the troubling discrepancies between the various models developed to understand MscS gating.
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影响因子：
3.4
作者：
Gullingsrud, J;Schulten, K
通讯作者：
Schulten, K
影响因子：
16.8
作者：
Edwards, MD;Li, YZ;Booth, IR
通讯作者：
Booth, IR
DOI：
10.1085/jgp.200910371
发表时间：
2010-06
期刊：
The Journal of general physiology
影响因子：
--
作者：
Belyy V;Kamaraju K;Akitake B;Anishkin A;Sukharev S
通讯作者：
Sukharev S
DOI：
10.1085/jgp.200409198
发表时间：
2005-02
期刊：
The Journal of general physiology
影响因子：
--
作者：
Akitake B;Anishkin A;Sukharev S
通讯作者：
Sukharev S
影响因子：
2.9
作者：
FELLE, H;PORTER, JS;KABACK, HR
通讯作者：
KABACK, HR