Interareal Spike-Train Correlations of Anterior Cingulate and Dorsal Prefrontal Cortex during Attention Shifts
Interareal Spike-Train Correlations of Anterior Cingulate and Dorsal Prefrontal Cortex during Attention Shifts
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DOI：
10.1523/jneurosci.1262-15.2015
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发表时间：
2015-09-23
影响因子：
5.3
通讯作者：
Womelsdorf, Thilo
中科院分区：
文献类型：
--
作者：
Oemisch, Mariann;Westendorff, Stephanie;Womelsdorf, Thilo
前扣带皮层（ACC）和前额叶皮层（PFC）被认为在目标导向行为中共同激活，以识别、选择和监测相关的感觉信息。在这里，我们测试了在空间注意任务的刺激选择过程中，猕猴ACC和PFC神经元的共激活是否在成对神经元相关水平上是明显的。我们发现，在注意提示后不久，放电相关性就出现了，在50-200 ms的时间窗内是明显的，在24区（ACC）和8区和9区（背侧PFC）的神经元对中最强，并且独立于整体放电速率调节。对于ACC和PFC背侧的一部分细胞对，观察到的功能性峰列连接携带了关于注意力转移方向的信息。具有宽尖峰波形的神经元（假定的兴奋性神经元）以及一对假定的兴奋性神经元和具有窄尖峰波形的神经元（假定的中间神经元）的区域边界之间明显存在可靠的放电相关性。这些发现表明，刺激选择伴随着与控制和监测注意力有关的ACC/PFC子区之间的缓慢时间尺度发射相关性。这种功能耦合提供了选择刺激的信息，从而可能索引了任务相关信息的交换。我们推测，在50-200毫秒的典型时间尺度上，区域间、瞬态放电相关性反映了更大的、相互作用的大脑网络的瞬态协调。
The anterior cingulate cortex (ACC) and prefrontal cortex (PFC) are believed to coactivate during goal-directed behavior to identify, select, and monitor relevant sensory information. Here, we tested whether coactivation of neurons across macaque ACC and PFC would be evident at the level of pairwise neuronal correlations during stimulus selection in a spatial attention task. We found that firing correlations emerged shortly after an attention cue, were evident for 50-200 ms time windows, were strongest for neuron pairs in area 24 (ACC) and areas 8 and 9 (dorsal PFC), and were independent of overall firing rate modulations. For a subset of cell pairs from ACC and dorsal PFC, the observed functional spike-train connectivity carried information about the direction of the attention shift. Reliable firing correlations were evident across area boundaries for neurons with broad spike waveforms (putative excitatory neurons) as well as for pairs of putative excitatory neurons and neurons with narrow spike waveforms (putative interneurons). These findings reveal that stimulus selection is accompanied by slow time scale firing correlations across those ACC/PFC subfields implicated to control and monitor attention. This functional coupling was informative about which stimulus was selected and thus indexed possibly the exchange of task-relevant information. We speculate that interareal, transient firing correlations reflect the transient coordination of larger, reciprocally interacting brain networks at a characteristic 50-200 ms time scale.