Synthesis of(+)-Muconin via Diastereoselective Oxypalladation
Synthesis of(+)-Muconin via Diastereoselective Oxypalladation
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通过非对映选择性氧化钯化合成( )-粘蛋白
DOI：
10.1021/acs.joc.0c02831
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Sugimoto;M.; Nosho;S.; Hikosaka;G.; Hattori;Y.; Umezawa;K.; Kawamura;A.; Makabe;H.
Synthesis of (+)-muconin isolated fromRollinia mucosa(Annonaceae) was achieved. Stereoselective construction of a tetrahydrofuran-terahydropyran (THF-THP) ring moiety was performed using diastereoselective oxypalladation in the presence of CuCl2. The cross-coupling reaction of the THF-THP moiety with the γ-lactone portion followed by reduction of the enyne and removal of the protecting groups afforded (+)-muconin.
