Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity
Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity
复制标题
DOI：
10.1067/mhj.2002.120772
复制
发表时间：
2002-03-01
影响因子：
4.8
通讯作者：
Giannuzzi, P
中科院分区：
文献类型：
--
作者：
Corrà, U;Mezzani, A;Giannuzzi, P
背景峰值耗氧量(Vo(2))对慢性心力衰竭(CHF)有重要的预后作用，但在中等运动量的患者(峰值Vo(2)在10-18mL/kg/min之间)其区分能力有限。方法对600例进行症状受限运动心肺功能试验的CHF患者进行筛查，随访780 450天。结果87例患者发生重大心脏事件，其中77例死亡，10例急诊心脏移植。多因素分析显示单位二氧化碳产生量增加的每分钟通气量增加率(VE/VCO(2)斜率)(x(2)，79.3，P
Background Peak oxygen consumption (Vo(2)) has an important prognostic role in chronic heart failure (CHF), but its discriminatory power is limited in patients with intermediate exercise capacity (peak Vo(2) between 10-18 mL/kg/min). Thus, supplementary exertional indexes are greatly needed.Methods Six hundred patients with CHF with left ventricular ejection fraction (LVEF) less than or equal to 40% who performed a symptom-limited cardiopulmonary exercise testing were screened and followed up for 780 450 days.Results Eighty-seven patients had major cardiac events (77 cardiac deaths and 10 urgent heart transplantations). Multivariate analysis revealed the rate of increase of minute ventilation per unit of increase of carbon dioxide production (VE/Vco(2) slope) (x(2), 79.3, P