The development of a European questionnaire for quality of life in patients with vertebral osteoporosis.
The development of a European questionnaire for quality of life in patients with vertebral osteoporosis.
复制标题
欧洲椎体骨质疏松症患者生活质量调查问卷的制定。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
I. Wiklund
中科院分区：
文献类型：
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作者：
Paul Lips;D. Agnusdei;F. Caulin;Cyrus Cooper;O. Johnell;J. Kanis;Uri A. Liberman;H. Minne;J. Reeve;J. Reginster;M. C. D. Vernejoul;I. Wiklund
椎体骨质疏松症的主诉通常是由楔形或挤压性骨折和双凹畸形引起的。这是由骨量减少和骨结构恶化导致强度丧失引起的。骨质疏松症的治疗应导致骨量的增加，新的椎体骨折的发生率应减少。然而，新的椎体骨折并不总是伴随疼痛，残疾与椎体骨折的数量也没有很好的相关性。骨质疏松症患者通常还有其他问题，例如洗澡、做饭、园艺、走楼梯、拜访朋友和参加社交活动。此外，疼痛和残疾可能会影响情绪，导致抑郁。生活质量的评估应该是骨质疏松症患者临床试验和个体患者护理的主要终点。最近，欧洲骨质疏松症基金会（EFFO）决定为椎体骨质疏松症患者（即椎体畸形患者）制定一份调查问卷。该问卷用于临床试验。问卷共48个问题，6个视觉模拟量表。这些问题涉及以下领域：疼痛、日常生活活动、房屋周围的工作、搬家、休闲和社交活动、总体健康感知和情绪。该问卷（“Qualeffo”）现已进入验证阶段。8个中心的第一项研究通过比较骨质疏松症患者和没有骨质疏松症或背痛的对照组，关注受试者内部的可重复性、内部一致性和特异性。
The complaints of vertebral osteoporosis usually result from wedge or crush fractures and biconcave deformities. These are caused by a decrease of bone mass and deterioration of bone structure leading to loss of strength. Treatment of osteoporosis should result in an increase of bone mass, and the incidence of new vertebral fractures should diminish. However, new vertebral fractures are not always accompanied by pain, and disability does not well correlate with the number of vertebral fractures. Patients with osteoporosis often have other problems e.g. with taking a shower, preparing meals, gardening, walking stairs, visiting friends and attending social activities. In addition, pain and disability may influence mood and lead to depression. The assessment of quality of life should be a primary endpoint in clinical trials in patients with osteoporosis and in individual patients care. Recently, the European Foundation for Osteoporosis (EFFO) has decided a develop a questionnaire for patients with vertebral osteoporosis, i.e. patients with vertebral deformities. The questionnaire is meant for use in clinical trials. A questionnaire was made including 48 questions and 6 visual analogue scales. The questions concern the following domains: pain, activities of daily living, jobs around the house, moving, leisure and social activities, general health perception and mood. The questionnaire ("Qualeffo") has now entered the validation phase. The first study in 8 centres concerns the within-subject reproducibility, the internal coherence, and the specificity by comparing osteoporotic patients with a control group not suffering from osteoporosis or backpain.